Outcomes for COPD pharmacological trials:: from lung function to biomarkers

被引：650

作者：

Cazzola, M. ^{[1
]}

MacNee, W. ^{[5
]}

Martinez, F. J. ^{[16
]}

Rabe, K. F. ^{[21
]}

Franciosi, L. G. ^{[6
]}

Barnes, P. J. ^{[7
]}

Brusasco, V. ^{[3
]}

Burge, P. S. ^{[11
]}

Calverley, P. M. A. ^{[15
]}

Celli, B. R. ^{[17
]}

Jones, P. W. ^{[8
]}

Mahler, D. A. ^{[18
]}

Make, B. ^{[19
]}

Miravitlles, M. ^{[24
]}

Page, C. P. ^{[9
]}

Palange, P. ^{[2
]}

Parr, D. ^{[13
,14
]}

Pistolesi, M. ^{[4
]}

Rennard, S. I.

Moelken, M. P. Rutten-Van ^{[22
]}

Stockley, R. ^{[12
]}

Sullivan, S. D. ^{[20
]}

Wedzicha, J. A. ^{[10
]}

Wouters, E. F. ^{[23
]}

机构：

[1] Univ Roma Tor Vergata, Unit Resp Dis, Dept Internal Med, I-00133 Rome, Italy

[2] Univ Roma La Sapienza, Rome, Italy

[3] Univ Genoa, Genoa, Italy

[4] Univ Florence, I-50121 Florence, Italy

[5] Colt Res Labs, Sch Med, Edinburgh, Midlothian, Scotland

[6] Kings Coll London, London, England

[7] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW7 2AZ, England

[8] Univ London, St Georges Hosp, London WC1E 7HU, England

[9] Kings Coll Hosp London, Sch Med, Sackler Inst Pulm Pharmacol, London, England

[10] UCL, London WC1E 6BT, England

[11] Birmingham Heartlands Hosp, Birmingham, W Midlands, England

[12] Queen Elizabeth Hosp, Birmingham, W Midlands, England

[13] Univ Hosp Covertry, Coventry, W Midlands, England

[14] Univ Hosp Warcickshire, Coventry, W Midlands, England

[15] Aintree Univ Hosp NHS Fdn Trust, Liverpool, Merseyside, England

[16] Univ Michigan, Sch Med, Ann Arbor, MI 48109 USA

[17] Caritas St Elizabeth Med Ctr, Boston, MA USA

[18] Dartmouth Hitchcock Med Ctr, Lebanon, NH 03766 USA

[19] Natl Jewish Med & Res Ctr, Denver, CO USA

[20] Univ Washington, Seattle, WA 98195 USA

[21] Leiden Univ, Med Ctr, Leiden, Netherlands

[22] Erasmus MC Univ, Med Ctr Rotterdam, Rotterdam, Netherlands

[23] Univ Hosp Maastricht, Maastricht, Netherlands

[24] Hosp Clin Barcelona, Barcelona, Spain

来源：

EUROPEAN RESPIRATORY JOURNAL | 2008年 / 31卷 / 02期

关键词：

D O I：

10.1183/09031936.00099306

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The American Thoracic Society/European Respiratory Society jointly created a Task Force on "Outcomes for COPD pharmacological trials: from lung function to biomarkers" to inform the chronic obstructive pulmonary disease research community about the possible use and limitations of current outcomes and markers when evaluating the impact of a pharmacological therapy. Based on their review of the published literature, the following document has been prepared with individual sections that address specific outcomes and markers, and a final section that summarises their recommendations.

引用

页码：416 / 468

页数：53

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