The sliding threshold of modification hypothesis: Application to the effect of hypothyroidism or chronic psychosocial stress and nicotine on synaptic plasticity

被引：9

作者：

Alzoubi, K. H. ^{[1
]}

Aleisa, A. M. ^{[1
]}

Alkadhi, K. A. ^{[1
]}

机构：

[1] Univ Houston, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA

来源：

NEUROSCIENCE LETTERS | 2008年 / 430卷 / 03期

关键词：

anesthetized rat; hippocampus; sliding threshold; theta(m); LTP; LTD;

D O I：

10.1016/j.neulet.2007.10.043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Bienenstock, Cooper, and Munro (BCM) theory or the sliding threshold model can be used to explain the changes in synaptic plasticity related to learning and memory, namely long-term potentiation (LTP) and depression (LTD). In this study, we applied synaptic plasticity changes induced by either chronic psychosocial stress or hypothyroidism, and their restoration by chronic nicotine treatment, to the sliding threshold model. Psychosocial stress- or hypothyroidism-induced changes in synaptic plasticity generated a shift in the sliding threshold of modification (theta m) toward LTD. In addition, chronic nicotine treatment restored the theta m to the normal position by normalizing psychosocial stress- or hypothyroidism-induced impairment of LTP and enhancement of LTD. The data correlate with our previous findings: a shift in the balance of kinase/phosphatase toward phosphatase during psychosocial stress or hypothyroidism, which is restored by chronic nicotine treatment. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：203 / 206

页数：4

共 33 条

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Aleisa, A. M. ;

Alzolubi, K. H. ;

Alkadhi, K. A. .

BRAIN RESEARCH, 2006, 1097 :78-84

[2] Chronic psychosocial stress-induced impairment of hippocampal LTP: Possible role of BDNF [J].

Aleisa, A. M. ;

Alzoubi, K. H. ;

Gerges, N. Z. ;

Alkadhi, K. A. .

NEUROBIOLOGY OF DISEASE, 2006, 22 (03) :453-462

[3] Nicotine blocks stress-induced impairment of spatial memory and long-term potentiation of the hippocampal CA1 region [J].

Aleisa, Abdulaziz M. ;

Alzoubi, Karem H. ;

Gerges, Nashaat Z. ;

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INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2006, 9 (04) :417-426

[4] Nicotine prevents stress-induced enhancement of long-term depression in hippocampal area CA1: Electrophysiological and molecular studies [J].

Aleisa, AM ;

Alzoubi, KH ;

Alkadhi, KA .

JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 83 (02) :309-317

[5] Psychosocial stress-induced hypertension results from in vivo expression of long-term potentiation in rat sympathetic ganglia [J].

Alkadhi, KA ;

Alzoubi, KH ;

Aleisa, AM ;

Tanner, FL ;

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NEUROBIOLOGY OF DISEASE, 2005, 20 (03) :849-857

[6] Adult-onset hypothyroidism facilitates and enhances LTD: Reversal by chronic nicotine treatment [J].

Alzoubi, K. H. ;

Aleisa, A. M. ;

Alkadhi, K. A. .

NEUROBIOLOGY OF DISEASE, 2007, 26 (01) :264-272

[7] A critical role of CREB in the impairment of late-phase LTP by adult onset hypothyroidism [J].

Alzoubi, K. H. ;

Alkadhi, K. A. .

EXPERIMENTAL NEUROLOGY, 2007, 203 (01) :63-71

[8] Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies [J].

Alzoubi, K. H. ;

Aleisa, A. M. ;

Gerges, N. Z. ;

Alkadhi, K. A. .

JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 84 (05) :944-953

[9] Molecular studies on the protective effect of nicotine in adult-onset hypothyroidism-induced impairment of long-term potentiation [J].

Alzoubi, K. H. ;

Aleisa, A. M. ;

Alkadhi, K. A. .

HIPPOCAMPUS, 2006, 16 (10) :861-874

[10] Levothyroxin restores hypothyroidism-induced impairment of UP of hippocampal CAI: Electrophysiological and molecular studies [J].

Alzoubi, KH ;

Gerges, NZ ;

Alkadhi, KA .

EXPERIMENTAL NEUROLOGY, 2005, 195 (02) :330-341

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