Loloatins A-D, cyclic decapeptide antibiotics produced in culture by a tropical marine bacterium

被引：51

作者：

Gerard, JM

Haden, P

Kelly, MT

Andersen, RJ

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Dept Oceanog Earth & Ocean Sci, Vancouver, BC V6T 1Z1, Canada

[3] Sea Tek Marine Biotechnol Inc, Surrey, BC V4A 7M4, Canada

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 01期

关键词：

D O I：

10.1021/np980219f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Loloatins A (1) to D (4), a family of new cyclic decapeptide antibiotics, have been isolated from laboratory cultures of a tropical marine bacterium recovered from the Great Barrier Reef in Papua New Guinea. The structures of loloatins A-D were elucidated via a combination of spectroscopic analyses and chemical degradation. Loloatins A-D exhibit in vitro antimicrobial activity against methicillin-resistant Staphyloccoccus aureus, vancomycin-resistant enterococci, and drug-resistant Streptococcus pneumoniae.

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页码：80 / 85

页数：6

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