A highly efficient synthesis of unnatural L-sugars from D-ribose

被引:53
作者
Yun, M
Moon, HR [1 ]
Kim, HO
Choi, WJ
Kim, YC
Park, CS
Jeong, LS
机构
[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea
[2] Ewha Womans Univ, Coll Pharm, Med Chem Lab, Seoul 120750, South Korea
[3] Gwaangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea
关键词
L-ribose; L-apiose; cis-dihydroxylation; hydroxymethylation;
D O I
10.1016/j.tetlet.2005.06.117
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A preparative and short synthesis of L-ribose and L-apiose was accomplished starting from D-ribose via stereoselective cis-dihydroxylation and C2-hydroxymethylation, respectively. These L-sugars can serve as versatile intermediates for the synthesis Of L-nucleosides. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5903 / 5905
页数:3
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