The biological functions of T helper 17 cell effector cytokines in inflammation

被引：1517

作者：

Ouyang, Wenjun ^{[1
]}

Kolls, Jay K. ^{[2
]}

Zheng, Yan ^{[3
]}

机构：

[1] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA

[2] Univ Pittsburgh, Childrens Hosp Pittsburgh, Dept Pediat, Div Pulm Med Allergy & Immunol, Pittsburgh, PA 15213 USA

[3] Pfizer Global Res & Dev, St Louis Labs, Inflammat Pathways Grp, Chesterfield, MO 63017 USA

来源：

IMMUNITY | 2008年 / 28卷 / 04期

关键词：

D O I：

10.1016/j.immuni.2008.03.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of interleukin-17A (IL-17A), IL-17F, IL-21, and IL-22. Th17 cells and their effector cytokines mediate host defensive mechanisms to various infections, especially extracellular bacteria infections, and are involved in the pathogenesis of many autoimmune diseases. The receptors for IL-17 and IL-22 are broadly expressed on various epithelial tissues. The effector cytokines of Th17 cells, therefore, mediate the crucial crosstalk between immune system and tissues, and play indispensable roles in tissue immunity.

引用

页码：454 / 467

页数：14

共 164 条

[71] IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells [J].

Korn, Thomas ;

Bettelli, Estelle ;

Gao, Wenda ;

Awasthi, Amit ;

Jaeger, Anneli ;

Strom, Terry B. ;

Oukka, Mohamed ;

Kuchroo, Vijay K. .

NATURE, 2007, 448 (7152) :484-U9

[72] Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity [J].

Kotenko, SV ;

Izotova, LS ;

Mirochnitchenko, OV ;

Esterova, E ;

Dickensheets, H ;

Donnelly, RP ;

Pestka, S .

JOURNAL OF IMMUNOLOGY, 2001, 166 (12) :7096-7103

[73] Identification of the functional interleukin-22 (IL-22) receptor complex -: The IL-10R2 chain (IL-10Rβ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes [J].

Kotenko, SV ;

Izotova, LS ;

Mirochnitchenko, OV ;

Esterova, E ;

Dickensheets, H ;

Donnelly, RP ;

Pestka, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) :2725-2732

[74] IL-22 is expressed by TH17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis [J].

Kreymborg, Katharina ;

Etzensperger, Ruth ;

Dumoutier, Laure ;

Haak, Stefan ;

Rebollo, Angelita ;

Buch, Thorsten ;

Heppner, Frank L. ;

Renauld, Jean-Christophe ;

Becher, Burkhard .

JOURNAL OF IMMUNOLOGY, 2007, 179 (12) :8098-8104

[75] A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis [J].

Krueger, Gerald G. ;

Langley, Richard G. ;

Leonardi, Craig ;

Yeilding, Newman ;

Guzzo, Cynthia ;

Wang, Yuhua ;

Dooley, Lisa T. ;

Lebwohl, Mark .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (06) :580-592

[76] Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F [J].

Kuestner, Rolf E. ;

Taft, David W. ;

Haran, Aaron ;

Brandt, Cameron S. ;

Brender, Ty ;

Lum, Karen ;

Harder, Brandon ;

Okada, Shannon ;

Ostrander, Craig D. ;

Kreindler, James L. ;

Aujla, Shean J. ;

Reardon, Brian ;

Moore, Margaret ;

Shea, Pamela ;

Schreckhise, Randall ;

Bukowski, Thomas R. ;

Presnell, Scott ;

Guerra-Lewis, Patricia ;

Parrish-Novak, Julia ;

Ellsworth, Jeff L. ;

Jaspers, Stephen ;

Lewis, Katherine E. ;

Appleby, Mark ;

Kolls, Jay K. ;

Rixon, Mark ;

West, James W. ;

Gao, Zeren ;

Levin, Steven D. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (08) :5462-5473

[77] IL-17-induced cytokine release in human bronchial epithelial cells in vitro:: role of mitogen-activated protein (MAP) kinases [J].

Laan, M ;

Lötvall, J ;

Chung, KF ;

Lindén, A .

BRITISH JOURNAL OF PHARMACOLOGY, 2001, 133 (01) :200-206

[78]

Laan M, 1999, J IMMUNOL, V162, P2347

[79] IL-23 drives a pathogenic T cell population that induces autoimmune inflammation [J].

Langrish, CL ;

Chen, Y ;

Blumenschein, WM ;

Mattson, J ;

Basham, B ;

Sedgwick, JD ;

McClanahan, T ;

Kastelein, RA ;

Cua, DJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :233-240

[80] IL-22, in contrast to IL-10, does not induce Ig production, due to absence of a functional IL-22 receptor on activated human B cells [J].

Lécart, S ;

Morel, F ;

Noraz, N ;

Pène, J ;

Garcia, M ;

Boniface, K ;

Lecron, JC ;

Yssel, H .

INTERNATIONAL IMMUNOLOGY, 2002, 14 (11) :1351-1356

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