Separation of platinum(II) anti-tumour drugs by micellar electrokinetic capillary chromatography

被引：42

作者：

Wenclawiak, BW

Wollmann, M

机构：

[1] Analytische Chemie I, Universität-GH Siegen, 57068 Siegen, Adolf-Reichwein-Strasse

来源：

JOURNAL OF CHROMATOGRAPHY A | 1996年 / 724卷 / 1-2期

关键词：

micellar electrokinetic chromatography; cisplatin; carboplatin; lobaplatin; platinum anti-tumour drugs;

D O I：

10.1016/0021-9673(95)00920-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Micellar electrokinetic capillary chromatography was used for the separation of platinum anti-tumour drugs in aqueous solutions. With the use of sodium dodecyl sulfate (SDS) the neutral drugs cisplatin, carboplatin and lobaplatin and charged hydrolysis products could be separated very easily in only one run. The pH of buffer solution, SDS concentration, applied voltage and injection conditions were optimized. The limit of detection and linearity for the determination of each complex were determined. The developed method was used for stability measurements of the complexes in solution.

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收藏

页码：317 / 326

页数：10

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