Molecular imaging with PET

被引：1033

作者：

Ametamey, Simon M. ^{[1
]}

Honer, Michael

Schubiger, Pius August

机构：

[1] ETH, Ctr Radiopharmaceut Sci, PSI, CH-8093 Zurich, Switzerland

来源：

CHEMICAL REVIEWS | 2008年 / 108卷 / 05期

关键词：

D O I：

10.1021/cr0782426

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of positron emission tomography (PET) imaging probes is necessary for molecular imaging. A review on some of the most important criteria necessary for a successful central nervous system (CNS) molecular probe has been discussed. A description on the radiolabeling strategies is given as well as on the most useful clinical PET radiopharmaceuticals that are useful for CNS and for the diagnosis of Alzheimer's disease. Furthermore, certain challenges on small animal PET imaging is also presented as well as its applications in rodent models of human brain diseases.

引用

页码：1501 / 1516

页数：16

共 166 条

[1]

Abott NJ, 2004, DRUG DISCOV TODAY, V1, P407

[2]

Ametamey SM, 2007, J NUCL MED, V48, P247

[3] PET studies of 18F-memantine in healthy volunteers [J].

Ametamey, SM ;

Bruehlmeier, M ;

Kneifel, S ;

Kokic, M ;

Honer, M ;

Arigoni, M ;

Buck, A ;

Burger, C ;

Samnick, S ;

Quack, G ;

Schubiger, PA .

NUCLEAR MEDICINE AND BIOLOGY, 2002, 29 (02) :227-231

[4]

Ametamey SM, 2006, J NUCL MED, V47, P698

[5] PALLADIUM-PROMOTED COUPLING REACTIONS OF [C-11] METHYL-IODIDE WITH ORGANOTIN AND ORGANOBORON COMPOUNDS [J].

ANDERSSON, Y ;

CHENG, AP ;

LANGSTROM, B .

ACTA CHEMICA SCANDINAVICA, 1995, 49 (09) :683-688

[6]

ANGELINI G, 1984, J LABELLED COMPD RAD, V21, P1223

[7]

BECAUD J, 2007, J LABELLED COMPD RAD, V50, pS215

[8]

Becherer A, 2004, J NUCL MED, V45, P1161

[9] Fluorine-18-labeled fluorine gas for synthesis of tracer molecules [J].

Bergman, J ;

Solin, O .

NUCLEAR MEDICINE AND BIOLOGY, 1997, 24 (07) :677-683

[10] Proton irradiation of [O-18]O-2: Production of [F-18]F-2 and [F-18]F-2+[F-18]OF2 [J].

Bishop, A ;

Satyamurthy, N ;

Bida, G ;

Hendry, G ;

Phelps, M ;

Barrio, JR .

NUCLEAR MEDICINE AND BIOLOGY, 1996, 23 (03) :189-199

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