Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry

被引：25

作者：

He, Y ^{[1
]}

Yang, J ^{[1
]}

Wu, BG ^{[1
]}

Robinson, D ^{[1
]}

Sprankle, K ^{[1
]}

Kung, PP ^{[1
]}

Lowery, K ^{[1
]}

Mohan, V ^{[1
]}

Hofstadler, S ^{[1
]}

Swayze, EE ^{[1
]}

Griffey, R ^{[1
]}

机构：

[1] Ibis Therapeut, Div Isis Pharmaceut Inc, Carlsbad, CA 92008 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 03期

关键词：

benzimidazoles; rRNA; mass spectrometry;

D O I：

10.1016/j.bmcl.2003.11.031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：695 / 699

页数：5

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