Finely Tuned Temperature-Controlled Cargo Release Using Paraffin-Capped Mesoporous Silica Nanoparticles

被引：137

作者：

Aznar, Elena ^{[1
,2
,3
]}

Mondragon, Laura ^{[1
,2
,3
]}

Ros-Lis, Jose V. ^{[1
,2
,3
]}

Sancenon, Felix ^{[1
,2
,3
]}

Dolores Marcos, M. ^{[1
,2
,3
]}

Martinez-Manez, Ramon ^{[1
,2
,3
]}

Soto, Juan ^{[1
,2
,3
]}

Perez-Paya, Enrique ^{[5
,6
]}

Amoros, Pedro ^{[4
]}

机构：

[1] Univ Valencia, Ctr Reconocimiento Mol & Desarrollo Tecnol IDM, Univ Politecn Valencia, Unidad Mixta, E-46003 Valencia, Spain

[2] Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain

[3] CIBER BBN, Zaragoza, Spain

[4] Univ Valencia, Inst Ciencia Mat ICMUV, Valencia 46071, Spain

[5] Ctr Invest Principe Felipe, Lab Peptidos & Prot, Valencia 46012, Spain

[6] CSIC, IBV, Valencia 46010, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 47期

关键词：

controlled release; drug delivery; mesoporous materials; molecular gates; nanoparticles; RESPONSIVE CONTROLLED-RELEASE; DRUG-DELIVERY; GUEST MOLECULES; SYSTEM; TRANSPORT; SUPPORTS; DESIGN; DRIVEN; SCAFFOLDINGS; SACCHARIDES;

D O I：

10.1002/anie.201102756

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trapped: Mesoporous silica nanoparticles were loaded with a fluorescent guest and functionalized with octadecyltrimethoxysilane. The alkyl chains interact with paraffins, which build a hydrophobic layer around the particle (see picture). Upon melting of the paraffin, the guest molecule is released, as demonstrated in cells for the guest doxorubicin. The release temperature can be tuned by choosing an appropriate paraffin. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11172 / 11175

页数：4

共 61 条

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