Phylogenetic and evolutionary analyses of St. Louis encephalitis virus genomes

被引：29

作者：

Baillie, Gregory J. ^{[1
]}

Kolokotronis, Sergios-Orestis ^{[1
]}

Waltari, Eric ^{[1
]}

Maffei, Joseph G. ^{[2
]}

Kramer, Laura D. ^{[2
]}

Perkins, Susan L. ^{[1
]}

机构：

[1] Amer Museum Nat Hist, Div Invertebrate Zool, New York, NY 10024 USA

[2] New York State Dept Hlth, Wadsworth Ctr, Arbovirus Labs, Slingerlands, NY 12159 USA

来源：

MOLECULAR PHYLOGENETICS AND EVOLUTION | 2008年 / 47卷 / 02期

关键词：

St. Louis encephalitis virus; Flavivirus; phylogeny; positive selection; recombination; N-linked glycosylation; divergence times;

D O I：

10.1016/j.ympev.2008.02.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

St. Louis encephalitis virus belongs to the Japanese encephalitis virus serocomplex of the genus Flavivirus, family Flaviviridae. Since the first known epidemic in 1933, the virus has been isolated from a variety of geographical, temporal, and host origins. We have sequenced 10,236 nucleotides of the open reading frame (93.6% of the full-length genome) of 23 of these strains, and have used the sequences to conduct phylogenetic analyses, in order to investigate the forces shaping the evolution of St. Louis encephalitis virus. Contrary to previous reports, we found little evidence for recombination in these isolates. Most of the amino acid sites in the SLEV polyprotein appeared to be under negative selection, with some sites evolving neutrally, and a small number under positive selection. The strongest signal for positive selection was evident in the N-linked glycosylation site of the envelope protein. Intra-strain sequence variability within strains was observed at this site, and analyses suggested that it is under selection in vitro. Furthermore, using heterochronous sequence data, we estimated the most recent expansion of St. Louis encephalitis virus in North America to have happened towards the end of the 19th century. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：717 / 728

页数：12

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