The effect of toll-like receptors and toll-like receptor genetics in human disease

被引：60

作者：

Garantziotis, Stavros ^{[1
,2
]}

Hollingsworth, John W. ^{[1
]}

Zaas, Aimee K. ^{[1
]}

Schwartz, David A. ^{[2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] NIEHS, Natl Toxicol Program, Res Triangle Pk, NC 27709 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2008年 / 59卷

关键词：

innate immunity; toll-like receptors; genomics; gene-environment interactions;

D O I：

10.1146/annurev.med.59.061206.112455

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Toll-like receptors (TLRs) enable innate immune recognition of endogenous and exogenous prototypic ligands. They also orchestrate innate and adaptive immune response to infection, inflammation, and tissue injury. Given their significance in the immune response, it is not surprising that genetic variations of TLRs can affect their function and by extension affect the response of the organism to environmental stimuli. The genetics of TLRs provides important insights in gene-environment interactions in health and disease, and it may enable scientists to assess patients' susceptibility to diseases or predict their response to treatments.

引用

页码：343 / 359

页数：17

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