Immunological Mechanisms Underneath the Efficacy of Cancer Therapy

被引：182

作者：

Galluzzi, Lorenzo ^{[1
,2
,3
,4
,5
,6
]}

Zitvogel, Laurence ^{[6
,7
,8
,9
]}

Kroemer, Guido ^{[2
,3
,4
,5
,10
,11
,12
]}

机构：

[1] Weill Cornell Med Coll, Dept Radiat Oncol, New York, NY USA

[2] Ctr Rech Cordeliers, Equipe Labellisee Ligue Canc 11, Paris, France

[3] INSERM, U1138, Paris, France

[4] Univ Paris Descartes Paris V, Sorbonne Paris Cite, Paris, France

[5] Univ Pierre & Marie Curie Paris VI, Paris, France

[6] Gustave Roussy Comprehens Canc Inst, Villejuif, France

[7] INSERM, U1015, Villejuif, France

[8] Ctr Clin Invest Biotherapies Canc CICBT 1428, Villejuif, France

[9] Univ Paris Sud Paris XI, Le Kremlin Bicetre, France

[10] Gustave Roussy Comprehens Canc Inst, Metab & Cell Biol Platforms, Villejuif, France

[11] Hop Europeen Georges Pompidou, Pole Biol, Paris, France

[12] Karolinska Univ Hosp, Dept Womens & Childrens Hlth, Stockholm, Sweden

来源：

CANCER IMMUNOLOGY RESEARCH | 2016年 / 4卷 / 11期

关键词：

MHC CLASS-I; TUMOR-INFILTRATING LYMPHOCYTES; REGULATORY T-CELLS; SUPPRESSOR-CELLS; LUNG-CANCER; COLORECTAL-CANCER; DENDRITIC CELLS; IFN-GAMMA; CALRETICULIN EXPOSURE; CHECKPOINT BLOCKADE;

D O I：

10.1158/2326-6066.CIR-16-0197

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Accumulating preclinical and clinical evidence indicates that the success of several anticancer agents-including some conventional chemotherapeutics, targeted anticancer agents as well as specific forms of radiotherapy-depends (at least in part) on their ability to stimulate anticancer immune responses. Such immunostimulatory effects can be "on-target," i.e., they originate within cancer cells, or "off-target," i.e., they develop from a heretofore unsuspected interaction between cancer therapy and the immune system. Here, we briefly discuss the immunologic mechanisms that underlie the efficacy of some forms of cancer therapy, as we highlight the rationale for combining these treatment modalities with immunotherapy to achieve superior therapeutic effects. (C) 2016 AACR.

引用

页码：895 / 902

页数：8

共 108 条

[1]

From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer [J].

Angel, Helen ;

Galon, Jerome .

CURRENT OPINION IN IMMUNOLOGY, 2013, 25 (02) :261-267

[2]

MHC Class I Loss Is a Frequent Mechanism of Immune Escape in Papillary Thyroid Cancer That Is Reversed by Interferon and Selumetinib Treatment In Vitro [J].

Angell, Trevor E. ;

Lechner, Melissa G. ;

Jang, Julie K. ;

LoPresti, Jonathan S. ;

Epstein, Alan L. .

CLINICAL CANCER RESEARCH, 2014, 20 (23) :6034-6044

[3]

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[4]

Combinatorial strategies for the induction of immunogenic cell death [J].

Bezu, Lucillia ;

Gomes-de-Silva, Ligia C. ;

Dewitte, Heleen ;

Breckpot, Karine ;

Fucikova, Jitka ;

Spisek, Radek ;

Galluzzi, Lorenzo ;

Kepp, Oliver ;

Kroemer, Guido .

FRONTIERS IN IMMUNOLOGY, 2015, 6

[5]

Prognostic Effect of Tumor Lymphocytic Infiltration in Resectable Non-Small-Cell Lung Cancer [J].

Brambilla, Elisabeth ;

Le Teuff, Gwenael ;

Marguet, Sophie ;

Lantuejoul, Sylvie ;

Dunant, Ariane ;

Graziano, Stephen ;

Pirker, Robert ;

Douillard, Jean-Yves ;

Le Chevalier, Thierry ;

Filipits, Martin ;

Rosell, Rafael ;

Kratzke, Robert ;

Popper, Helmut ;

Soria, Jean-Charles ;

Shepherd, Frances A. ;

Seymour, Lesley ;

Tsao, Ming Sound .

JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (11) :1223-+

[6]

HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C [J].

Braud, VM ;

Allan, DSJ ;

O'Callaghan, CA ;

Söderström, K ;

D'Andrea, A ;

Ogg, GS ;

Lazetic, S ;

Young, NT ;

Bell, JI ;

Phillips, JH ;

Lanier, LL ;

McMichael, AJ .

NATURE, 1998, 391 (6669) :795-799

[7]

Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications [J].

Buque, Aitziber ;

Bloy, Norma ;

Aranda, Fernando ;

Castoldi, Francesca ;

Eggermont, Alexander ;

Cremer, Isabelle ;

Fridman, Wolf Herve ;

Fucikova, Jitka ;

Galon, Jerome ;

Marabelle, Aurelien ;

Spisek, Radek ;

Tartour, Eric ;

Zitvogel, Laurence ;

Kroemer, Guido ;

Galluzzi, Lorenzo .

ONCOIMMUNOLOGY, 2015, 4 (04)

[8]

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death [J].

Casares, N ;

Pequignot, MO ;

Tesniere, A ;

Ghiringhelli, F ;

Roux, S ;

Chaput, N ;

Schmitt, E ;

Hamai, A ;

Hervas-Stubbs, S ;

Obeid, M ;

Coutant, F ;

Métivier, D ;

Pichard, E ;

Aucouturier, P ;

Pierron, G ;

Garrido, C ;

Zitvogel, L ;

Kroemer, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (12) :1691-1701

[9]

Natural killer cell memory in infection, inflammation and cancer [J].

Cerwenka, Adelheid ;

Lanier, Lewis L. .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (02) :112-123

[10]

Mutational Landscape and Sensitivity to Immune Checkpoint Blockers [J].

Chabanon, Roman M. ;

Pedrero, Marion ;

Lefebvre, Celine ;

Marabelle, Aurelien ;

Soria, Jean-Charles ;

Postel-Vinay, Sophie .

CLINICAL CANCER RESEARCH, 2016, 22 (17) :4309-4321

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