From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer

被引：531

作者：

Angel, Helen ^{[1
,2
,3
]}

Galon, Jerome ^{[1
,2
,3
]}

机构：

[1] INSERM, U872, Lab Integrat Canc Immunol, Paris, France

[2] Univ Paris 05, Paris, France

[3] Univ Paris 06, Ctr Rech Cordeliers, Paris, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2013年 / 25卷 / 02期

关键词：

TUMOR-INFILTRATING LYMPHOCYTES; CD8(+) T-LYMPHOCYTES; GROWTH-FACTOR-BETA; CELL LUNG-CANCER; COLORECTAL-CANCER; BREAST-CANCER; CLINICAL-SIGNIFICANCE; SURVIVAL; EXPRESSION; IMPACT;

D O I：

10.1016/j.coi.2013.03.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The inherent complexity of multifactorial diseases such as cancer renders the process of patient prognosis and prediction of response to therapy extremely difficult. Many markers, signatures, and methods have been described to evaluate the prognosis of cancer patients, yet very few translate into the clinic. Systems biology approaches have facilitated analysis of the complex interaction between tumors and the host-immune response, and allowed the definition of the immune contexture. Here we review the potential of the immune contexture, quantified by the Immunoscore, to provide a statistically strong parameter for prognosis. Finally we introduce the concept that the host-immune reaction could be the critical element in determining response to therapy. The effect on the immune response could be the underlying factor behind many of the predictive markers.

引用

页码：261 / 267

页数：7

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