Natural immunity to cancer in humans

被引：180

作者：

Bindea, Gabriela ^{[1
,2
,3
]}

Mlecnik, Bernhard ^{[1
,2
,3
]}

Fridman, Wolf-Herman ^{[2
,3
,4
,5
]}

Pages, Franck ^{[1
,2
,3
,5
]}

Galon, Jerome ^{[1
,2
,3
,5
]}

机构：

[1] INSERM, U872, Integrat Canc Immunol Team, F-75006 Paris, France

[2] Univ Paris 05, Paris, France

[3] Univ Paris 06, Cordeliers Res Ctr, Paris, France

[4] INSERM, U872, Team 13, F-75006 Paris, France

[5] HEGP, AP HP, Paris, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 02期

关键词：

REGULATORY T-CELLS; COLORECTAL-CANCER; PROGNOSTIC-SIGNIFICANCE; TUMOR-DEVELOPMENT; SYSTEMS BIOLOGY; GENE ONTOLOGY; HIGH NUMBERS; JC VIRUS; KAPPA-B; SURVIVAL;

D O I：

10.1016/j.coi.2010.02.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The evolution of cancer reflects intricate cellular and molecular interactions of tumor cells with the tumor microenvironment. Novel systems biology approaches are emerging to analyze the complex interaction between tumors and host-immune response in humans. The opposing host-protective and tumor-promoting roles of the immune system reflect the disparate effects of immunity on tumorigenesis. Global analysis of tumor microenvironment showed that a strong adaptive immune reaction within primary human tumors reduced the risk of relapse events. Recent advances support the existence of immunosurveillance in human cancer. The major role of the intratumoral immune reaction could advance our understanding of tumor evolution and have important consequences in clinical practice.

引用

收藏

页码：215 / 222

页数：8

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