Plasma levels of andrenomedullin in primary and secondary pulmonary hypertension in patients <20 years of age

被引：62

作者：

Yoshibayashi, M

Kamiya, T

Kitamura, K

Saito, Y

Kangawa, K

Nishikimi, T

Matsuoka, H

Eto, T

Matsuo, H

机构：

[1] NATL CARDIOVASC CTR,DEPT PEDIAT,SUITA,OSAKA 565,JAPAN

[2] MIYAZAKI MED COLL,DEPT INTERNAL MED 1,MIYAZAKI 88916,JAPAN

[3] NATL CARDIOVASC CTR,RES INST,SUITA,OSAKA 565,JAPAN

[4] NATL CARDIOVASC CTR,DIV HYPERTENS & NEPHROL,SUITA,OSAKA 565,JAPAN

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1997年 / 79卷 / 11期

关键词：

SMOOTH-MUSCLE CELLS; VASCULAR-DISEASE; LUNG-BIOPSY; ADRENOMEDULLIN;

D O I：

10.1016/S0002-9149(97)00195-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To elucidate the pathophysiologic significance of adrenomedullin in pulmonary hypertension, we measured plasma adrenomedullin-like immunoreactivity (AM-LI) concentrations in blood samples obtained from various sites during cardiac catheterization by using radioimmunoassay in patients with pulmonary hypertension in comparison with patients without pulmonary hypertension. In patients with pulmonary hypertension, plasma AM-LI concentrations were significantly elevated and there was a significant uptake of AM-LI in pulmonary circulation, indicating the involvement of adrenomedullin in the cardiovascular regulation of pulmonary circulation in pulmonary hypertension.

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收藏

页码：1556 / &

页数：4

相关论文

共 10 条

[1] SPECIFIC RECEPTORS FOR ADRENOMEDULLIN IN CULTURED RAT VASCULAR SMOOTH-MUSCLE CELLS [J].

EGUCHI, S ;

HIRATA, Y ;

KANO, H ;

SATO, K ;

WATANABE, Y ;

WATANABE, TX ;

NAKAJIMA, K ;

SAKAKIBARA, S ;

MARUMO, F .

FEBS LETTERS, 1994, 340 (03) :226-230

[2] ADRENOMEDULLIN AS A NOVEL ANTIMIGRATION FACTOR OF VASCULAR SMOOTH-MUSCLE CELLS [J].

HORIO, T ;

KOHNO, M ;

KANO, H ;

IKEDA, M ;

YASUNARI, K ;

YOKOKAWA, K ;

MINAMI, M ;

TAKEDA, T .

CIRCULATION RESEARCH, 1995, 77 (04) :660-664

[3] ADRENOMEDULLIN STIMULATES CYCLIC-AMP FORMATION IN RAT VASCULAR SMOOTH-MUSCLE CELLS [J].

ISHIZAKA, Y ;

ISHIZAKA, Y ;

TANAKA, M ;

KITAMURA, K ;

KANGAWA, K ;

MINAMINO, N ;

MATSUO, H ;

ETO, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 200 (01) :642-646

[4] Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cells [J].

Kano, H ;

Kohno, M ;

Yasunari, K ;

Yokokawa, K ;

Horio, T ;

Ikeda, M ;

Minami, M ;

Hanehira, T ;

Takeda, T ;

Yoshikawa, J .

JOURNAL OF HYPERTENSION, 1996, 14 (02) :209-213

[5] ADRENOMEDULLIN - A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA [J].

KITAMURA, K ;

KANGAWA, K ;

KAWAMOTO, M ;

ICHIKI, Y ;

NAKAMURA, S ;

MATSUO, H ;

ETO, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 192 (02) :553-560

[6] CLONING AND CHARACTERIZATION OF CDNA-ENCODING A PRECURSOR FOR HUMAN ADRENOMEDULLIN [J].

KITAMURA, K ;

SAKATA, J ;

KANGAWA, K ;

KOJIMA, M ;

MATSUO, H ;

ETO, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 194 (02) :720-725

[7] IMMUNOREACTIVE ADRENOMEDULLIN IN HUMAN PLASMA [J].

KITAMURA, K ;

ICHIKI, Y ;

TANAKA, M ;

KAWAMOTO, M ;

EMURA, J ;

SAKAKIBARA, S ;

KANGAWA, K ;

MATSUO, H ;

ETO, T .

FEBS LETTERS, 1994, 341 (2-3) :288-290

[8]

LAFARGE CG, 1970, CARDIOVASC RES, V4, P237

[9] LUNG-BIOPSY IN CONGENITAL HEART-DISEASE - MORPHOMETRIC APPROACH TO PULMONARY VASCULAR-DISEASE [J].

RABINOVITCH, M ;

HAWORTH, SG ;

CASTANEDA, AR ;

NADAS, AS ;

REID, LM .

CIRCULATION, 1978, 58 (06) :1107-1122

[10] LUNG-BIOPSY SPECIMENS IN THE EVALUATION OF PULMONARY VASCULAR-DISEASE [J].

WAGENVOORT, CA .

CHEST, 1980, 77 (05) :614-625