Metabolic Flux and the Regulation of Mammalian Cell Growth

被引：359

作者：

Locasale, Jason W. ^{[1
,2
]}

Cantley, Lewis C. ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Div Signal Transduct, Boston, MA 02215 USA

来源：

CELL METABOLISM | 2011年 / 14卷 / 04期

基金：

美国国家卫生研究院;

关键词：

AEROBIC GLYCOLYSIS; PYRUVATE-KINASE; CARBOHYDRATE-METABOLISM; ION-TRANSPORT; HIF-ALPHA; PROTEIN; CANCER; TRANSCRIPTION; MECHANISMS; ACETYLATION;

D O I：

10.1016/j.cmet.2011.07.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The study of normal mammalian cell growth and the defects that contribute to disease pathogenesis links metabolism to cell growth. Here, we visit several aspects of growth-promoting metabolism, emphasizing recent advances in our understanding of how alterations in glucose metabolism affect cytosolic and mitochondrial redox potential and ATP generation. These alterations drive cell proliferation not only through supporting biosynthesis, energy metabolism, and maintaining redox potential but also through initiating signaling mechanisms that are still poorly characterized. The evolutionary basis of these additional layers of growth control is also discussed.

引用

收藏

页码：443 / 451

页数：9

相关论文

共 69 条

[1]

[Anonymous], 1924, Biochem Z

[2] The Sir2 family of protein deacetylases [J].

Blander, G ;

Guarente, L .

ANNUAL REVIEW OF BIOCHEMISTRY, 2004, 73 :417-435

[3] Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast [J].

Brauer, Matthew J. ;

Huttenhower, Curtis ;

Airoldi, Edoardo M. ;

Rosenstein, Rachel ;

Matese, John C. ;

Gresham, David ;

Boer, Viktor M. ;

Troyanskaya, Olga G. ;

Botstein, David .

MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (01) :352-367

[4] The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor [J].

Brown, MS ;

Goldstein, JL .

CELL, 1997, 89 (03) :331-340

[5] Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes [J].

Cai, Ling ;

Sutter, Benjamin M. ;

Li, Bing ;

Tu, Benjamin P. .

MOLECULAR CELL, 2011, 42 (04) :426-437

[6] Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions [J].

Choudhary, Chunaram ;

Kumar, Chanchal ;

Gnad, Florian ;

Nielsen, Michael L. ;

Rehman, Michael ;

Walther, Tobias C. ;

Olsen, Jesper V. ;

Mann, Matthias .

SCIENCE, 2009, 325 (5942) :834-840

[7] Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake [J].

Christensen, Brock C. ;

Kelsey, Karl T. ;

Zheng, Shichun ;

Houseman, E. Andres ;

Marsit, Carmen J. ;

Wrensch, Margaret R. ;

Wiemels, Joseph L. ;

Nelson, Heather H. ;

Karagas, Margaret R. ;

Kushi, Lawrence H. ;

Kwan, Marilyn L. ;

Wiencke, John K. .

PLOS GENETICS, 2010, 6 (07) :1-10

[8] The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth [J].

Christofk, Heather R. ;

Vander Heiden, Matthew G. ;

Harris, Marian H. ;

Ramanathan, Arvind ;

Gerszten, Robert E. ;

Wei, Ru ;

Fleming, Mark D. ;

Schreiber, Stuart L. ;

Cantley, Lewis C. .

NATURE, 2008, 452 (7184) :230-U74

[9] Pyruvate kinase M2 is a phosphotyrosine-binding protein [J].

Christofk, Heather R. ;

Vander Heiden, Matthew G. ;

Wu, Ning ;

Asara, John M. ;

Cantley, Lewis C. .

NATURE, 2008, 452 (7184) :181-U27

[10] Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions [J].

D'Amours, D ;

Desnoyers, S ;

D'Silva, I ;

Poirier, GG .

BIOCHEMICAL JOURNAL, 1999, 342 :249-268

← 1 2 3 4 5 6 7 →