Next-Generation Sequencing-Based Panel Testing for Myeloid Neoplasms

被引：24

作者：

Kuo, Frank C. ^{[1
]}

Dong, Fei ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Adv Mol Diagnost,Dept Pathol, Boston, MA 02115 USA

来源：

CURRENT HEMATOLOGIC MALIGNANCY REPORTS | 2015年 / 10卷 / 02期

关键词：

Next-generation sequencing; Myeloid neoplasm; Acute myeloid leukemia; Myelodysplastic syndromes; CHRONIC MYELOMONOCYTIC LEUKEMIA; INTERNAL TANDEM DUPLICATION; MYELODYSPLASTIC SYNDROMES; SOMATIC MUTATIONS; SETBP1; MUTATIONS; MYELOPROLIFERATIVE NEOPLASMS; PROGNOSTIC-SIGNIFICANCE; CLONAL HEMATOPOIESIS; RECURRENT MUTATIONS; DNMT3A MUTATIONS;

D O I：

10.1007/s11899-015-0256-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Our ability to interrogate a broad array of genetic alterations in myeloid neoplasm has increased significantly with the advance in next-generation sequencing (NGS). In addition to morphologic examination, flow cytometry, and cytogenetics, NGS-based testing can add additional information to the diagnostic workup. More than a dozen myeloid-focused NGS-based panels are now available from commercial and academic laboratories. In this review, we examine the content of these panels in the context of our current understanding of driver alterations in myeloid neoplasms. With improved turnaround time, decreasing costs, and an expanding knowledge of the therapeutic and prognostic significance of the detected variants, NGS-based panel testing is likely to play a major role in the management of patients with myeloid neoplasm in the coming decade.

引用

页码：104 / 111

页数：8

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