Altered circadian rhythmicity is an early sign of murine dietary thiamine deficiency

被引：13

作者：

Bennett, MR ^{[1
]}

Schwartz, WJ ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA 01655 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1999年 / 163卷 / 01期

关键词：

circadian rhythm; locomotor activity; suprachiasmatic nucleus; thiamine; Wernicke encephalopathy; C57BL/6J inbred mice;

D O I：

10.1016/S0022-510X(99)00004-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine if circadian clock function is affected by thiamine deficiency, the rhythm of locomotor (wheel-running) activity was measured in a murine model of dietary thiamine deficiency. About 1 month before the expected onset of overt neurological illness, locomotor rhythmicity in deficient animals exhibited a shortened free-running period without a change in amplitude. This effect was fully reversible by thiamine administration. Disordered circadian timekeeping may contribute to altered physiological responses in Wernicke's encephalopathy. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：6 / 10

页数：5

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