Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4

被引：56

作者：

Mohri, Yasuaki ^{[1
]}

Kato, Shigeki ^{[1
]}

Umezawa, Akihiro ^{[2
]}

Okuyama, Ryuhei ^{[3
]}

Nishimori, Katsuhiko ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Mol Biol Lab, Aoba Ku, Sendai, Miyagi 9818555, Japan

[2] Natl Res Inst Child Hlth & Dev, Tokyo, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Dermatol, Sendai, Miyagi 9818555, Japan

来源：

DEVELOPMENTAL DYNAMICS | 2008年 / 237卷 / 08期

关键词：

LGR4; GPR48; GPCR; gene deletion mice; hair follicle;

D O I：

10.1002/dvdy.21639

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

We observed that Lgr4(K5) (KO) mice had sparse head hair and focal alopecia behind their ears, as observed in tabby (Eda) and downless (Edar) mice, which are models of the human genetic disorder hypohidrotic (anhidrotic) ectodermal dysplasia (HED). Lgr4-deficient mice showed partial impairment in hair follicle development with reduced expression of Edar, Lef1, and Shh, which were essential for hair follicle morphogenesis, in the epidermis. Immunohistochemical analysis of Lgr4(-/-) mice epidermis using shh antibody showed reduced numbers of hair placodes, and we also detected higher phosphorylation of Smad(1/5/8), which is required to suppress normal hair follicle induction. We suspected that Lgr4 might be a novel gene class regulating the development of hair follicles.

引用

页码：2235 / 2242

页数：8

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