(S)-(+)-N-acetylphenylglycineboronic acid:: A chiral derivatizing agent for Ee determination of 1,2-diols

被引：21

作者：

Caselli, E ^{[1
]}

Danieli, C ^{[1
]}

Morandi, S ^{[1
]}

Bonfiglio, B ^{[1
]}

Forni, A ^{[1
]}

Prati, F ^{[1
]}

机构：

[1] Univ Modena, I-41100 Modena, Italy

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 25期

关键词：

D O I：

10.1021/ol0359970

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new chiral derivatizing agent for ee determination of 1,2-diols via H-1 NMR is described. (S)-(+)-N-Acetylphenylglycineboronic acid (1) is synthesized in enantiomerically pure form; its reaction with chiral diols quantitatively yields cyclic boronic esters 5a-g. The latter show a remarkably high diastereodifferentiation of proton NMR signals useful for de determination.

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页码：4863 / 4866

页数：4

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