Combinatorial approaches to affinity chromatography

被引：97

作者：

Lowe, CR ^{[1
]}

机构：

[1] Univ Cambridge, Inst Biotechnol, Cambridge CB2 1QT, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(00)00199-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new armoury of protein purification tools is required to support rapid advances in high-throughput genomics and proteomics, which are predicted to lead to the discovery. isolation, characterisation and manufacture of a number of new biopharmaceutical proteins. Computer-aided molecular design, combinatorial (bio)chemistry and high-throughput screening techniques are now being exploited to identify highly selective ligands for use in the purification of these proteins by affinity chromatography.

引用

页码：248 / 256

页数：9

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