MicroRNA regulation and interspecific variation of gene expression

被引：54

作者：

Cui, Qinghua ^{[1
]}

Yu, Zhenbao ^{[1
]}

Purisima, Enrico O. ^{[1
]}

Wang, Edwin ^{[1
]}

机构：

[1] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 08期

关键词：

D O I：

10.1016/j.tig.2007.04.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

MicroRNAs (miRNAs) modulate expression of their target genes in various tissues and at different developmental stages, but it is unclear whether they drive cross-species variation in gene expression. By comparing data from mammal and fly species we found that the cross-species expression variation of miRNA targets is significantly lower than that of other genes. This implies that miRNAs can affect gene expression by reducing stochastic noise, buffering cross-species variation and constraining evolutionary gene expression variation.

引用

页码：372 / 375

页数：4

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