The Golgi complex: perspectives and prospectives

被引:8
作者
Jamieson, JD [1 ]
机构
[1] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1998年 / 1404卷 / 1-2期
关键词
sorting; trafficking; Golgi complex; perspective; vesicular transport;
D O I
10.1016/S0167-4889(98)00043-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We now have considerable understanding of the role of the Golgi complex in the posttranslational modifications of membrane and secretory proteins and of lysosomal hydrolases. It is now also clear that the Golgi plays a key role in the intracellular packaging, addressing, and sorting of these classes of proteins to their final destinations on the secretory and endocytic pathways. While it has been proposed that vesicular budding and fusion underlie entry of proteins into the Golgi from the ER and subsequent movement among its cisternae and exit to their final stations, recent observations indicate that this model may need to be revised based on studies in living cells where vesicular-tubular structures appear to mediate membrane trafficking. This will be a major challenge for investigators in the coming years who will rely again on the use of morphologic techniques of the sort that started it all in 1898. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:3 / 8
页数:6
相关论文
共 30 条
[1]   COPII - A MEMBRANE COAT THAT FORMS ENDOPLASMIC RETICULUM-DERIVED VESICLES [J].
BARLOWE, C .
FEBS LETTERS, 1995, 369 (01) :93-96
[2]   TUBULOVESICULAR PROCESSES EMERGE FROM TRANS-GOLGI CISTERNAE, EXTEND ALONG MICROTUBULES, AND INTERLINK ADJACENT TRANS-GOLGI ELEMENTS INTO A RETICULUM [J].
COOPER, MS ;
CORNELLBELL, AH ;
CHERNJAVSKY, A ;
DANI, JW ;
SMITH, SJ .
CELL, 1990, 61 (01) :135-145
[3]   PATHWAYS TO REGULATED EXOCYTOSIS IN NEURONS [J].
DECAMILLI, P ;
JAHN, R .
ANNUAL REVIEW OF PHYSIOLOGY, 1990, 52 :625-645
[4]   CAVEOLAE AND SORTING IN THE TRANS-GOLGI NETWORK OF EPITHELIAL-CELLS [J].
DUPREE, P ;
PARTON, RG ;
RAPOSO, G ;
KURZCHALIA, TV ;
SIMONS, K .
EMBO JOURNAL, 1993, 12 (04) :1597-1605
[5]   THE GOLGI-APPARATUS (COMPLEX) (1954-1981) FROM ARTIFACT TO CENTER STAGE [J].
FARQUHAR, MG ;
PALADE, GE .
JOURNAL OF CELL BIOLOGY, 1981, 91 (03) :S77-S103
[6]   PROGRESS IN UNRAVELING PATHWAYS OF GOLGI TRAFFIC [J].
FARQUHAR, MG .
ANNUAL REVIEW OF CELL BIOLOGY, 1985, 1 :447-488
[7]   VIP36, A NOVEL COMPONENT OF GLYCOLIPID RAFTS AND EXOCYTIC CARRIER VESICLES IN EPITHELIAL-CELLS [J].
FIEDLER, K ;
PARTON, RG ;
KELLNER, R ;
ETZOLD, T ;
SIMONS, K .
EMBO JOURNAL, 1994, 13 (07) :1729-1740
[8]   THE TRANS GOLGI NETWORK - SORTING AT THE EXIT SITE OF THE GOLGI-COMPLEX [J].
GRIFFITHS, G ;
SIMONS, K .
SCIENCE, 1986, 234 (4775) :438-443
[9]  
HENDRICKS LC, 1991, J BIOL CHEM, V266, P17559
[10]   INTRACELLULAR TRANSPORT OF SECRETORY PROTEINS IN PANCREATIC EXOCRINE CELL .2. TRANSPORT TO CONDENSING VACUOLES AND ZYMOGEN GRANULES [J].
JAMIESON, JD ;
PALADE, GE .
JOURNAL OF CELL BIOLOGY, 1967, 34 (02) :597-+