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COPII - A MEMBRANE COAT THAT FORMS ENDOPLASMIC RETICULUM-DERIVED VESICLES

被引：31
作者：
BARLOWE, C
机构：
来源：
FEBS LETTERS | 1995年 / 369卷 / 01期
关键词：
INTRACELLULAR TRANSPORT; VESICLE BUDDING; COAT PROTEIN; ENDOPLASMIC RETICULUM;
D O I：
10.1016/0014-5793(95)00618-J
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vesicle budding from the endoplasmic reticulum (ER) has been reconstituted with washed membranes and three soluble proteins: Sec13 complex, Sec23 complex and the small GTPase Sar1p. The proteins that drive this cell-free vesicle budding reaction form an similar to 10 nm thick electron dense coat on ER-derived vesicles. Although the overall mechanism of membrane budding driven by various cytoplasmic coats appears similar, the constituents of this new membrane coat are molecularly distinct from the non-clathrin coat (COP) involved in intra-Golgi transport and the clathrin-containing coats. The new vesicle coat has been termed COPII.
引用
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页码：93 / 96
页数：4
相关论文
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