Metabolism of fluorine-containing drugs

被引：525

作者：

Park, BK ^{[1
]}

Kitteringham, NR ^{[1
]}

O'Neill, PM ^{[1
]}

机构：

[1] Univ Liverpool, Dept Pharmacol & Therapeut, Liverpool L69 3BX, Merseyside, England

来源：

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2001年 / 41卷

关键词：

drug metabolism; drug toxicity; drug design; drug safety; defluorination; metabolic stability;

D O I：

10.1146/annurev.pharmtox.41.1.443

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.

引用

页码：443 / 470

页数：28

共 109 条

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