Fast and efficient microwave-assisted synthesis of functionalized peptoids via Ugi reactions

被引：38

作者：

Barreto, Angelica de Fatima S. ^{[1
]}

Vercillo, Otilie E. ^{[1
]}

Birkett, Mike A. ^{[2
]}

Caulfield, John C. ^{[2
]}

Wessjohann, Ludger A. ^{[3
]}

Andrade, Carlos Kleber Z. ^{[1
]}

机构：

[1] Univ Brasilia, Inst Quim, Lab Quim Metodol & Organ Sintet LaQMOS, BR-70910970 Brasilia, DF, Brazil

[2] Ctr Sustainable Pest & Dis Management, Biol Chem Dept, Harpenden AL5 2JQ, Herts, England

[3] Leibniz Inst Plant Biochem, Dept Bioorgan Chem, D-06120 Halle, Saale, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 14期

关键词：

ONE-POT; MULTICOMPONENT REACTIONS; ORGANIC SYNTHESES; CLICK CHEMISTRY; DESIGN; MACROCYCLIZATIONS; OLIGOMERS; FIT;

D O I：

10.1039/c1ob05471f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide range of N-alkylglycines (peptoids) can be efficiently prepared via Ugi reactions using microwave irradiations. The results confirm the versatility and efficiency of the methodology for the preparation of functionalized peptoids. The products can be used in consecutive Ugi reactions to yield cyclic peptoids of potential biological interest.

引用

页码：5024 / 5027

页数：4

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