Expanding on the purification methodology of polyethylene glycol (PEG) bound molecules: The synthesis of 3,5-pyrazolidinediones

被引：61

作者：

Zhao, XY

Metz, WA

Sieber, F

Janda, KD

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 46期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(98)01921-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isopropanol was found to be an excellent solvent for the precipitation of PEG-bound molecules; Polar reagents and by-products, even those generated as a result of using benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP) or benzotriazol-1-yloxy-tripyrrolidinophosphonium hexafluorophosphate (PyBOP) coupling reagents, are soluble in iPrOH allowing clean precipitation of the polymer-bound species. Several examples are given to support the general utility of this precipitation method which allowed for the synthesis of a 3,5-pyrazolidinedione on soluble PEG polymer support. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8433 / 8436

页数：4

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