The Increasing Burden of HIV-Associated Malignancies in Resource-Limited Regions

被引：69

作者：

Casper, Corey ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[3] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA

[4] Univ Washington, Dept Med, Seattle, WA 98195 USA

[5] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[6] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

来源：

ANNUAL REVIEW OF MEDICINE, VOL 62, 2011 | 2011年 / 62卷

关键词：

HIV; cancer; sub-Saharan Africa; Kaposi sarcoma; lymphoma; hepatocellular carcinoma; HUMAN-IMMUNODEFICIENCY-VIRUS; SARCOMA-ASSOCIATED HERPESVIRUS; ACTIVE ANTIRETROVIRAL THERAPY; HEPATITIS-B VACCINATION; KAPOSIS-SARCOMA; IMMUNE RECONSTITUTION; INFECTED PATIENTS; HEPATOCELLULAR-CARCINOMA; PROTEASE INHIBITOR; NEUTRALIZING ANTIBODIES;

D O I：

10.1146/annurev-med-050409-103711

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cancer is increasingly recognized as a complication of MT infection in both resource-rich and resource-limited areas. The traditional AIDS-defining cancers, including Kaposi sarcoma, cervical cancer, and non-Hodgkin lymphoma, have become common comorbidities afflicting HIV-positive individuals and lack adequate prevention and management options. Additionally, several non-AIDS-defining cancers have increased in incidence in resource-limited regions, including Hodgkin lymphoma, hepatocellular carcinoma, and lung cancer. This review outlines the epidemiology of HIV-associated malignancies in resource-poor and resource-rich areas, including the impact of highly active antiretroviral therapy on the incidence of these cancers. The pathogenesis of HIV-associated cancers is considered in relation to potential strategies for their prevention and treatment.

引用

页码：157 / 170

页数：14

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