PKC-delta and PKC-epsilon: Foes of the same family or strangers?

被引：106

作者：

Duquesnes, Nicolas ^{[2
,3
,4
]}

Lezoualc'h, Frank ^{[5
,6
]}

Crozatier, Bertrand ^{[1
,7
]}

机构：

[1] INSERM, UMRS 769, Fac Pharm, F-92296 Chatenay Malabry, France

[2] INSERM, UMR S915, Inst Thorax, Nantes, France

[3] CNRS, URL3147, Nantes, France

[4] Univ Nantes, Nantes, France

[5] INSERM, UMR 1048, Inst Malad Metab & Cardiovasc, F-31342 Toulouse, France

[6] Univ Toulouse 3, F-31342 Toulouse, France

[7] Univ Paris 11, Orsay, France

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2011年 / 51卷 / 05期

关键词：

Protein kinase C; Signal transduction; Activation; Localization; Structure; PROTEIN-KINASE-C; OVERLOAD CARDIAC-HYPERTROPHY; CRYSTAL-STRUCTURE; PHORBOL ESTER; IN-VIVO; SUBCELLULAR-LOCALIZATION; PHOSPHOLIPASE-C; BINDING DOMAIN; HEART-FAILURE; PERMEABILITY TRANSITION;

D O I：

10.1016/j.yjmcc.2011.07.013

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Protein kinase C (PKC) is a family of 10 serine/threonine kinases divided into 3 subfamilies, classical, novel and atypical classes. Two PKC isozymes of the novel group, PKC epsilon and PKC delta, have different and sometimes opposite effects. PKC epsilon stimulates cell growth and differentiation while PKC delta is apoptotic. In the heart, they are among the most expressed PKC isozymes and they are opposed in the preconditioning process with a positive role of PKC epsilon and an inhibiting role of PKC delta. The goal of this review is to analyze the structural differences of these 2 enzymes that may explain their different behaviors and properties. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：665 / 673

页数：9

共 122 条

[1]

14-3-3 PROTEINS - A HIGHLY CONSERVED, WIDESPREAD FAMILY OF EUKARYOTIC PROTEINS [J].

AITKEN, A ;

COLLINGE, DB ;

VANHEUSDEN, BPH ;

ISOBE, T ;

ROSEBOOM, PH ;

ROSENFELD, G ;

SOLL, J .

TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (12) :498-501

[2]

14-3-3 proteins: A historic overview [J].

Aitken, Alastair .

SEMINARS IN CANCER BIOLOGY, 2006, 16 (03) :162-172

[3]

Mitochondrial PKCε and MAPK form signaling modules in the murine heart -: Enhanced mitochondrial PKCε-MAPK interactions and differential MAPK activation in PKCε-induced cardioprotection [J].

Baines, CP ;

Zhang, J ;

Wang, GW ;

Zheng, YT ;

Xiu, JX ;

Cardwell, EM ;

Bolli, R ;

Ping, P .

CIRCULATION RESEARCH, 2002, 90 (04) :390-397

[4]

Protein kinase Cε interacts with and inhibits the permeability transition pore in cardiac mitochondria [J].

Baines, CP ;

Song, CX ;

Zheng, YT ;

Wang, GW ;

Zhang, J ;

Wang, OL ;

Guo, Y ;

Bolli, R ;

Cardwell, EM ;

Ping, PP .

CIRCULATION RESEARCH, 2003, 92 (08) :873-880

[5]

The C2 domain of PKCδ is a phosphotyrosine binding domain [J].

Benes, CH ;

Wu, N ;

Elia, AEH ;

Dharia, T ;

Cantley, LC ;

Soltoff, SP .

CELL, 2005, 121 (02) :271-280

[6]

CHARACTERIZATION OF PROTEIN-KINASE-C ISOTYPE EXPRESSION IN ADULT-RAT HEART - PROTEIN-KINASE C-EPSILON IS A MAJOR ISOTYPE PRESENT, AND IT IS ACTIVATED BY PHORBOL ESTERS, EPINEPHRINE, AND ENDOTHELIN [J].

BOGOYEVITCH, MA ;

PARKER, PJ ;

SUGDEN, PH .

CIRCULATION RESEARCH, 1993, 72 (04) :757-767

[7]

Protein kinase C-α and -ε modulate connexin-43 phosphorylation in human heart [J].

Bowling, N ;

Huang, XD ;

Sandusky, GE ;

Fouts, RL ;

Mintze, K ;

Esterman, M ;

Allen, PD ;

Maddi, R ;

McCall, E ;

Vlahos, CJ .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (04) :789-798

[8]

Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart [J].

Bowling, N ;

Walsh, RA ;

Song, GJ ;

Estridge, T ;

Sandusky, GE ;

Fouts, RL ;

Mintze, K ;

Pickard, T ;

Roden, R ;

Bristow, MR ;

Sabbah, HN ;

Mizrahi, JL ;

Gromo, G ;

King, GL ;

Vlahos, CJ .

CIRCULATION, 1999, 99 (03) :384-391

[9]

Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cδ in the intact cell [J].

Braun, DC ;

Garfield, SH ;

Blumberg, PM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (09) :8164-8171

[10]

Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy [J].

Braun, MU ;

LaRosée, P ;

Simonis, G ;

Borst, MM ;

Strasser, RH .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2004, 262 (1-2) :135-143

← 1 2 3 4 5 6 7 8 9 10 →