14-3-3 proteins: A historic overview

被引:692
作者
Aitken, Alastair [1 ]
机构
[1] Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3JR, Midlothian, Scotland
基金
英国惠康基金;
关键词
14-3-3; proteins; history; phospho-binding motifs; protein interactions; protein kinases;
D O I
10.1016/j.semcancer.2006.03.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the differences between potentially cancer-relevant isoforms on the genomic, protein and functional level. The focus will therefore be on mammalian 14-3-3s although many important developments in the field have involved Drosophila 14-3-3 proteins for example and the cross-fertilisation from parallel studies on plant 14-3-3 should not be underestimated. In the major part of this review I will attempt to focus on some novel data and aspects of 14-3-3 structure and function, in particular regulation of 14-3-3 isoforms by oncogene-related protein kinase phosphorylation and aspects of 14-3-3 research with which newcomers to the field may be less familiar. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:162 / 172
页数:11
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