Catalysed synthesis of 4-heptanone from 1-butanol

被引：31

作者：

Plint, N ^{[1
]}

Ghavalas, D ^{[1
]}

Vally, T ^{[1
]}

Sokolovski, VD ^{[1
]}

Coville, NJ ^{[1
]}

机构：

[1] Univ Witwatersrand, Dept Chem, Appl Chem & Chem Technol Ctr, ZA-2050 Wits, South Africa

来源：

CATALYSIS TODAY | 1999年 / 49卷 / 1-3期

关键词：

heptanone; butanol; magnesium oxide; cerium oxide;

D O I：

10.1016/S0920-5861(98)00410-6

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

While investigating the reaction of 1-butanol over base catalysts, such as MgO, we observed the formation of small amounts of 4-heptanone. Further studies revealed that a CeO2/MgO catalyst gave good selectivity to this product. To optimise the reaction and determine the reaction mechanism a series of studies were undertaken in which a range of variables were modified viz. cerium loading, temperature, reagent composition and water addition. The optimum conditions for 4-heptanone yield (25.5%) and selectivity (42.5%) were found to be: 450 degrees C, 1:6 oxygen to butanol reagent mixture and a total gas flow rate of 6.74 ml/min. A reaction mechanism in which butanol is oxidised to butanal and then butanoic acid followed by the coupling of two equivalents of butanoic acid to give the symmetrical ketone 4-heptanone and CO2 is proposed. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：71 / 77

页数：7