Genetics of morphogen gradients

被引：100

作者：

Tabata, T ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan

来源：

NATURE REVIEWS GENETICS | 2001年 / 2卷 / 08期

关键词：

D O I：

10.1038/35084577

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The organization of cells and tissues is controlled by the action of 'form-giving' signalling molecules, or morphogens, which pattern a developmental field in a concentration-dependent manner. As the fate of each cell in the field depends on the level of the morphogen signal, the concentration gradient of the morphogen prefigures the pattern of development. In recent years, molecular genetic studies in Drosophila melanogaster have allowed tremendous progress in understanding how morphogen gradients are formed and maintained, and the mechanism by which receiving cells respond to the gradient.

引用

页码：620 / 630

页数：11

共 101 条

[81] Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker [J].

Sivasankaran, R ;

Vigano, MA ;

Müller, B ;

Affolter, M ;

Basler, K .

EMBO JOURNAL, 2000, 19 (22) :6162-6172

[82] Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation [J].

St-Jacques, B ;

Hammerschmidt, M ;

McMahon, AP .

GENES & DEVELOPMENT, 1999, 13 (16) :2072-2086

[83] The EXT2 multiple exostoses gene defines a family of putative tumour suppressor genes [J].

Stickens, D ;

Clines, G ;

Burbee, D ;

Ramos, P ;

Thomas, S ;

Hogue, D ;

Hecht, JT ;

Lovett, M ;

Evans, GA .

NATURE GENETICS, 1996, 14 (01) :25-32

[84] Wingless gradient formation in the Drosophila wing [J].

Strigini, M ;

Cohen, SM .

CURRENT BIOLOGY, 2000, 10 (06) :293-300

[85]

Strigini M, 1997, DEVELOPMENT, V124, P4697

[86]

TABATA T, 1995, DEVELOPMENT, V121, P3359

[87] HEDGEHOG IS A SIGNALING PROTEIN WITH A KEY ROLE IN PATTERNING DROSOPHILA IMAGINAL DISKS [J].

TABATA, T ;

KORNBERG, TB .

CELL, 1994, 76 (01) :89-102

[88] Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs [J].

Tanimoto, H ;

Itoh, S ;

ten Dijke, P ;

Tabata, T .

MOLECULAR CELL, 2000, 5 (01) :59-71

[89] Dpp gradient formation in the Drosophila wing imaginal disc [J].

Teleman, AA ;

Cohen, SM .

CELL, 2000, 103 (06) :971-980

[90] Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan [J].

The, I ;

Bellaiche, Y ;

Perrimon, N .

MOLECULAR CELL, 1999, 4 (04) :633-639

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