A short guided tour through functional and structural features of saposin-like proteins

被引：167

作者：

Bruhn, H ^{[1
]}

机构：

[1] Res Ctr Infect Dis, D-97070 Wurzburg, Germany

来源：

BIOCHEMICAL JOURNAL | 2005年 / 389卷

关键词：

antimicrobial activity; innate immunity; lipid metabolism; lipid-binding; membrane interaction; saposin-like protein;

D O I：

10.1042/BJ20050051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SAPLIPs (saposin-like proteins) are a diverse family of lipid-interacting proteins that have various and only partly understood, but nevertheless essential, cellular functions. Their existence is conserved in phylogenetically most distant organisms, such as primitive protozoa and mammals. Owing to their remarkable sequence variability, a common mechanism for their actions is not known. Some shared principles beyond their diversity have become evident by analysis of known three-dimensional structures. Whereas lipid interaction is the basis for their functions, the special cellular tasks are often defined by interaction partners other than lipids. Based on recent findings, this review summarizes phylogenetic relations, function and structural features of the members of this family.

引用

页码：249 / 257

页数：9

共 100 条

[61] Prosaposin: a new player in cell death prevention of U937 monocytic cells [J].