A2144G is the main mutation in the 23S rRNA gene of Helicobacter pylori associated with clarithromycin resistance

被引：3

作者：

Momynaliev, KT ^{[1
]}

Selezneva, OV ^{[1
]}

Kozlova, AA ^{[1
]}

Vereshchagin, VA ^{[1
]}

Il'ina, EN ^{[1
]}

Govorun, VM ^{[1
]}

机构：

[1] Res Inst Physicochem Med, Moscow 119992, Russia

来源：

RUSSIAN JOURNAL OF GENETICS | 2005年 / 41卷 / 10期

关键词：

D O I：

10.1007/s11177-005-0205-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To detect point mutations A2115C, A2143G/C, and A2144G in the 23S rRNA gene of Helicobacter pylori associated with resistance of the microorganism to clarithromycin, a new powerful way of analysis was used. This method involved the reaction of minisequencing followed by MALDI-TOF mass spectrometry of reaction products. In ten analyzed clarithromycin-resistant clinical isolates of H. pylori obtained in Russia, the resistance was found to be mediated only by mutation A2144G in the 23S rRNA gene.

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页码：1095 / 1100

页数：6

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