β-catenin interacts with MyoD and regulates its transcription activity

被引：67

作者：

Kim, Chang-Hoon ^{[1
,2
,3
]}

Neiswender, Hannah ^{[1
,2
]}

Baik, Eun Joo ^{[3
]}

Xiong, Wen C. ^{[1
,2
]}

Mei, Lin ^{[1
,2
]}

机构：

[1] Med Coll Georgia, Inst Mol Med & Genet, Program Dev Neurobiol, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Neurol, Augusta, GA 30912 USA

[3] Ajou Univ, Sch Med, Neurosci Grad Program BK21, Chron Inflammatory Dis Res Ctr,Dept Physiol, Suwon 443749, South Korea

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2008年 / 28卷 / 09期

关键词：

D O I：

10.1128/MCB.01682-07

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Wnt regulation of muscle development is thought to be mediated by the beta-catenin-TCF/LEF-dependent canonical pathway. Here we demonstrate that beta-catenin, not TCF/LEF, is required for muscle differentiation. We showed that beta-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E box elements and transcriptional activity. MyoD-mediated transactivation is inhibited in muscle cells when beta-catenin is deficient or the interaction between MyoD and beta-catenin is disrupted. These results demonstrate that beta-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway.

引用

页码：2941 / 2951

页数：11

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