HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease

被引：49

作者：

Guo, Yi ^{[1
,2
,3
]}

Deng, Xiong ^{[1
]}

Zheng, Wen ^{[4
]}

Xu, Hongbo ^{[1
]}

Song, Zhi ^{[4
]}

Liang, Hui ^{[1
]}

Lei, Jin ^{[1
,4
]}

Jiang, Xuhong ^{[4
]}

Luo, Ziqiang ^{[2
]}

Deng, Hao ^{[1
,4
]}

机构：

[1] Cent S Univ, Ctr Med Expt, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China

[2] Cent S Univ, Dept Physiol, Xiangya Med Sch, Changsha 410013, Hunan, Peoples R China

[3] Cent S Univ, Dept Med Informat, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China

[4] Cent S Univ, Dept Neurol, Xiangya Hosp 3, Changsha 410013, Hunan, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2011年 / 501卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Late-onset sporadic Parkinson disease; HLA-DRA; Rs3129882; Association; GENOME-WIDE ASSOCIATION; REACTIVE MICROGLIA; SUBSTANTIA-NIGRA; T-CELLS; RISK; GENE; POPULATION; EXPRESSION; SEQUENCE;

D O I：

10.1016/j.neulet.2011.05.245

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Recently, the rs3129882 variant in intron 1 of HLA-DRA was found to be associated with late-onset sporadic Parkinson disease (PD) in Americans of European ancestry. To evaluate whether the same variant is related to PD in Chinese population, we investigated late-onset sporadic PD patients of Chinese Han ethanicity in Mainland China. We found significant difference in genotypic and allele distribution between patients and control subjects (chi(2)=6.446, p=0.040 for genotypic distribution; chi(2)=5.762, p=0.016 for allele distribution), suggesting this variant is associated with late-onset sporadic PD in Chinese Han population. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：185 / 187

页数：3

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