Vaccinia virus immune evasion

被引：44

作者：

Smith, GL ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

IMMUNOLOGY LETTERS | 1999年 / 65卷 / 1-2期

基金：

英国惠康基金;

关键词：

vaccinia virus; immune evasion; chemokines; eotaxin; chemokine binding protein; complement; complement control proteins; CD55; CD59; CD46; antibody neutralisation; virus morphogenesis;

D O I：

10.1016/S0165-2478(98)00125-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Vaccinia virus expresses many virulence factors that are non-essential for virus replication in cell culture but are important in vivo. In this paper three mechanisms are described that are used by vaccinia virus to evade the host immune response to infection. One of these is the release of a soluble protein that binds CC chemokines and that is unrelated to cellular chemokine receptors. The other two mechanisms are displayed by virus particles that are released from infected cells. This form of vaccinia virus is called extracellular enveloped virus (EEV) and is resistant to neutralisation by antibody and to destruction by complement. Resistance to complement is mediated by the acquisition of host complement control proteins, particularly CD55, during virus release from infected cells. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：55 / 62

页数：8

共 43 条

[11] SEQUENCE-ANALYSIS OF HINDIII Q2 FRAGMENT OF CAPRIPOXVIRUS REVEALS A PUTATIVE GENE ENCODING A G-PROTEIN-COUPLED CHEMOKINE RECEPTOR HOMOLOG [J].

CAO, JX ;

GERSHON, PD ;

BLACK, DN .

VIROLOGY, 1995, 209 (01) :207-212

[12] STRUCTURAL AND FUNCTIONAL-ANALYSIS OF ORTHOPOXVIRUS EPITOPES WITH NEUTRALIZING MONOCLONAL-ANTIBODIES [J].

CZERNY, CP ;

MAHNEL, H .

JOURNAL OF GENERAL VIROLOGY, 1990, 71 :2341-2352

[13] Chemokines and HIV-1 second receptors - Confluence of two fields generates optimism in AIDS research [J].

DSouza, MP ;

Harden, VA .

NATURE MEDICINE, 1996, 2 (12) :1293-1300

[14] A CONSTITUTIVELY EXPRESSED VACCINIA GENE ENCODES A 42-KDA GLYCOPROTEIN RELATED TO COMPLEMENT CONTROL FACTORS THAT FORMS PART OF THE EXTRACELLULAR VIRUS ENVELOPE [J].

ENGELSTAD, M ;

HOWARD, ST ;

SMITH, GL .

VIROLOGY, 1992, 188 (02) :801-810

[15] THE COMPLETE DNA-SEQUENCE OF VACCINIA VIRUS [J].

GOEBEL, SJ ;

JOHNSON, GP ;

PERKUS, ME ;

DAVIS, SW ;

WINSLOW, JP ;

PAOLETTI, E .

VIROLOGY, 1990, 179 (01) :247-266

[16] The T1/35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues [J].

Graham, KA ;

Lalani, AS ;

Macen, JL ;

Ness, TL ;

Barry, M ;

Liu, LY ;

Lucas, A ;

ClarkLewis, A ;

Moyer, RW ;

McFadden, G .

VIROLOGY, 1997, 229 (01) :12-24

[17] Extracellular enveloped vaccinia virus escapes neutralization [J].

Ichihashi, Y .

VIROLOGY, 1996, 217 (02) :478-485

[18] BIOGENESIS OF POXIVRUSES - ROLE OF A-TYPE INCLUSIONS AND HOST CELL MEMBRANES IN VIRUS DISSEMINATION [J].

ICHIHASHI, Y ;

MATSUMOTO, S ;

DALES, S .

VIROLOGY, 1971, 46 (03) :507-+

[19]

Jezek Z., 1988, HUMAN MONKEYPOX, V17

[20] VACCINIA VIRUS ENCODES A SECRETORY POLYPEPTIDE STRUCTURALLY RELATED TO COMPLEMENT CONTROL PROTEINS [J].

KOTWAL, GJ ;

MOSS, B .

NATURE, 1988, 335 (6186) :176-178

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