Synthesis of the skipped polyene chain and its neighboring highly oxygenated pyran ring en route to delivering the C(43)-C(67) subsector of amphidinol 3

被引：31

作者：

Chang, SK ^{[1
]}

Paquette, LA ^{[1
]}

机构：

[1] Ohio State Univ, Evans Chem Labs, Columbus, OH 43210 USA

来源：

SYNLETT | 2005年 / 19期

关键词：

polyketide metabolite; carbohydrate homologation; selective desilylation; Julia-Lythgoe reaction; Julia-Kocienski reaction;

D O I：

10.1055/s-2005-918960

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An approach toward a total synthesis of amphidinol 3 that focuses on elaboration of the C(43)-C(67) subunit is described. The Julia-Kocienski reaction constitutes a straightforward way to unite the skipped polyolefin chain to the adjacent highly functionalized pyran ring.

引用

页码：2915 / 2918

页数：4

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