MicroRNAs and Stem Cells Control of Pluripotency, Reprogramming, and Lineage Commitment

被引：110

作者：

Heinrich, Eva-Marie ^{[1
]}

Dimmeler, Stefanie ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Internal Med 3, Ctr Mol Med, Inst Cardiovasc Regenerat, D-60590 Frankfurt, Germany

来源：

CIRCULATION RESEARCH | 2012年 / 110卷 / 07期

基金：

欧洲研究理事会;

关键词：

differentiation; epigenetics; microRNA; stem cells; CARDIAC DIFFERENTIATION; HUMAN FIBROBLASTS; PROGENITOR CELLS; GENE-EXPRESSION; MOUSE; ANGIOGENESIS; DICER; PROLIFERATION; MODULATE; CLUSTER;

D O I：

10.1161/CIRCRESAHA.111.243394

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stem cells hold great promise for regenerative medicine and the treatment of cardiovascular diseases. The mechanisms regulating self-renewal, pluripotency, and differentiation are not fully understood. MicroRNAs (miRs) are small noncoding RNAs controlling gene expression, either by inducing mRNA degradation or by blocking mRNA translation. The expression of miRs was shown to regulate various aspects of stem cell functions, including the maintenance and induction of pluripotency for reprogramming. In addition, some miRs control cell fate decisions. This review summarizes the role of miRs in reprogramming and embryonic stem cell self-renewal, and specifically addresses the regulation of cardiovascular cell fate decisions by miRs. (Circ Res. 2012;110:1014-1022.)

引用

页码：1014 / 1022

页数：9

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