Prostate imaging based on RF spectrum analysis and non-linear classifiers for guiding biopsies and targeting radiotherapy

被引:4
作者
Feleppa, EJ [1 ]
Ketterling, JA [1 ]
Kalisz, A [1 ]
Urban, S [1 ]
Porter, CR [1 ]
Gillespie, J [1 ]
Schiff, PB [1 ]
Ennis, RD [1 ]
Wuu, CS [1 ]
Moul, JW [1 ]
Sesterhenn, IA [1 ]
Scardino, PT [1 ]
机构
[1] Riverside Res Inst, New York, NY 10036 USA
来源
MEDICAL IMAGING 2001: ULTRASONIC IMAGING AND SIGNAL PROCESSING | 2001年 / 4325卷
关键词
prostate cancer; ultrasonic imaging; spectrum analysis; neural networks; brachytherapy; external-beam radiation; tissue-typing; non-linear classification; ROC curves; therapy guidance;
D O I
10.1117/12.428213
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Conventional B-mode ultrasound is the standard means of imaging the prostate for guiding prostate biopsies and planning radiotherapy (i.e., brachytherapy and external-beam radiation) of prostate cancer (CaP). Yet B-mode images essentially do not allow visualization of cancerous lesions of the prostate. Ultrasonic tissue-typing imaging based on spectrum analysis of radiofrequency (RF) echo signals has shown promise for overcoming the limitations of B-mode imaging in distinguishing cancerous from common forms of non-cancerous prostate tissue. Such tissue typing utilizes non-linearmethods, such as nearest-neighbor and neural-network techniques, to classify tissues based on spectral-parameter and clinical-variable values. Our research seeks to develop imaging techniques based on these methods for the purpose of improving the guidance of prostate biopsies and the targeting of brachytherapy and external-beam. radiotherapy of prostate cancer. Images based on these methods have been imported into real-time instrumentation for biopsy guidance and into commercial dose-planning software for real-time brachytherapy. Three-dimensional renderings show locations and volumes of cancer foci. These methods offer exciting possibilities for effective low-cost depiction of prostate cancer in real-time and off-line images. Real-time imaging showing cancerous regions of the prostate can be of value in directing biopsies, determining whether biopsy is warranted, assisting in clinical staging, targeting brachytherapy, planning conformal external-beam radiation procedures, and monitoring treatment.
引用
收藏
页码:371 / 379
页数:9
相关论文
共 9 条
[1]   REPEAT PROSTATE NEEDLE-BIOPSY - WHO NEEDS IT [J].
ELLIS, WJ ;
BRAWER, MK .
JOURNAL OF UROLOGY, 1995, 153 (05) :1496-1498
[2]   Three-dimensional ultrasonic parametric and tissue-property imaging for tissue evaluation, treatment planning, therapy guidance, and efficacy assessment [J].
Feleppa, EJ ;
Liu, T ;
Lizzi, FL ;
Kalisz, A ;
Silverman, RH ;
Sigel, B ;
Fair, WR .
MEDICAL IMAGING 2000: ULTRASONIC IMAGING AND SIGNAL PROCESSING, 2000, 3982 :68-76
[3]   Two-dimensional and three-dimensional tissue-type imaging of the prostate based on ultrasonic spectrum analysis and neural-network classification [J].
Feleppa, EJ ;
Fair, WR ;
Liu, T ;
Kalisz, A ;
Gnadt, W ;
Lizzi, FL ;
Balaji, KC ;
Porter, CC ;
Tsai, H .
MEDICAL IMAGING 2000: ULTRASONIC IMAGING AND SIGNAL PROCESSING, 2000, 3982 :152-160
[4]  
Feleppa EJ, 2000, MOL UROL, V4, P133
[5]   DIAGNOSTIC SPECTRUM ANALYSIS IN OPHTHALMOLOGY - A PHYSICAL PERSPECTIVE [J].
FELEPPA, EJ ;
LIZZI, FL ;
COLEMAN, DJ ;
YAREMKO, MM .
ULTRASOUND IN MEDICINE AND BIOLOGY, 1986, 12 (08) :623-631
[6]  
Feleppa EJ, 1999, MOL UROL, V3, P303
[7]   THEORETICAL FRAMEWORK FOR SPECTRUM ANALYSIS IN ULTRASONIC TISSUE CHARACTERIZATION [J].
LIZZI, FL ;
GREENEBAUM, M ;
FELEPPA, EJ ;
ELBAUM, M ;
COLEMAN, DJ .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1983, 73 (04) :1366-1373
[8]   RELATIONSHIP OF ULTRASONIC SPECTRAL PARAMETERS TO FEATURES OF TISSUE MICROSTRUCTURE [J].
LIZZI, FL ;
OSTROMOGILSKY, M ;
FELEPPA, EJ ;
RORKE, MC ;
YAREMKO, MM .
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 1987, 34 (03) :319-329
[9]   Analysis of repeated biopsy results within 1 year after a noncancer diagnosis - Reply [J].
O'Dowd, GJ ;
Miller, MC ;
Orozco, R ;
Veltri, RW .
UROLOGY, 2000, 55 (04) :559-559