The histamine H4 receptor as a new therapeutic target for inflammation

被引：210

作者：

de Esch, IJP

Thurmond, RL

Jongejan, A

Leurs, R

机构：

[1] Vrije Univ Amsterdam, Leiden Amsterdam Ctr Drug Res, Dept Med Chem, NL-1081 HV Amsterdam, Netherlands

[2] Johnson & Johnson Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 09期

关键词：

D O I：

10.1016/j.tips.2005.07.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H-4 receptor has a distinct pharmacological profile and the first compounds that act selectively on the H-4 receptor have been developed. Initial experiments in vivo with H-4 receptor antagonists indicate a role for the H-4 receptor in inflammatory conditions.

引用

收藏

页码：462 / 469

页数：8

相关论文

共 59 条

[51] Increase in epithelial mast cell numbers in the nasal mucosa of patients with perennial allergic rhinitis [J].

Slater, A ;

Smallman, LA ;

DrakeLee, AB .

JOURNAL OF LARYNGOLOGY AND OTOLOGY, 1996, 110 (10) :929-933

[52] Inverse agonism of histamine H-2 antagonists accounts for upregulation of spontaneously active histamine H-2 receptors [J].

Smit, MJ ;

Leurs, R ;

Alewijnse, AE ;

Blauw, J ;

Amerongen, GPV ;

VandeVrede, Y ;

Roovers, E ;

Timmerman, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6802-6807

[53] Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: Comparison with carrageenan [J].

Takeshita, K ;

Bacon, KB ;

Gantner, F .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 310 (01) :272-280

[54] Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo [J].

Takeshita, K ;

Sakai, K ;

Bacon, KB ;

Gantner, F .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 307 (03) :1072-1078

[55] Snythesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists [J].

Terzioglu, N ;

van Rijn, RM ;

Bakker, RA ;

De Esch, IJP ;

Leurs, R .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (21) :5251-5256

[56] A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties [J].

Thurmond, RL ;

Desai, PJ ;

Dunford, PJ ;

Fung-Leung, WP ;

Hofstra, CL ;

Jiang, W ;

Nguyen, S ;

Riley, JP ;

Sun, SQ ;

Williams, KN ;

Edwards, JP ;

Karlsson, L .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2004, 309 (01) :404-413

[57] Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production [J].

Voehringer, D ;

Shinkai, K ;

Locksley, RM .

IMMUNITY, 2004, 20 (03) :267-277

[58]

Wieland K, 2001, J PHARMACOL EXP THER, V299, P908

[59] Cloning, expression, and pharmacological characterization of a novel human histamine receptor [J].

Zhu, Y ;

Michalovich, D ;

Wu, HL ;

Tan, KB ;

Dytko, GM ;

Mannan, IJ ;

Boyce, R ;

Alston, J ;

Tierney, LA ;

Li, XT ;

Herrity, NC ;

Vawter, L ;

Sarau, HM ;

Ames, RS ;

Davenport, BM ;

Hieble, JP ;

Wilson, S ;

Bergsma, DJ ;

Fitzgerald, LR .

MOLECULAR PHARMACOLOGY, 2001, 59 (03) :434-441

← 1 2 3 4 5 6 →