Discovery and development of safe-in-man broad-spectrum antiviral agents

被引：178

作者：

Andersen, Petter I. ^{[1
]}

Ianevski, Aleksandr ^{[1
]}

Lysvand, Hilde ^{[1
]}

Vitkauskiene, Astra ^{[2
]}

Oksenych, Valentyn ^{[1
]}

Bjoras, Magnar ^{[1
]}

Telling, Kaidi ^{[3
]}

Lutsar, Irja ^{[4
]}

Dumpis, Uga ^{[5
]}

Irie, Yasuhiko ^{[3
]}

Tenson, Tanel ^{[3
]}

Kantele, Anu ^{[6
,7
]}

Kainov, Denis E. ^{[1
,3
,8
]}

机构：

[1] Norwegian Univ Sci & Technol NTNU, Dept Clin & Mol Med, N-7028 Trondheim, Norway

[2] Lithuanian Univ Hlth Sci, Dept Lab Med, LT-44307 Kaunas, Lithuania

[3] Univ Tartu, Inst Technol, EE-50090 Tartu, Estonia

[4] Univ Tartu, Inst Med Microbiol, EE-50411 Tartu, Estonia

[5] Latvian Biomed Res & Study Ctr, LV-1067 Riga, Latvia

[6] Helsinki Univ Hosp HUS, Helsinki 00290, Finland

[7] Univ Helsinki, Helsinki 00290, Finland

[8] Univ Helsinki, Inst Mol Med Finland, FIMM, Helsinki 00014, Finland

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2020年 / 93卷

关键词：

Virus; Antiviral drug; Drug discovery and development; Broad-spectrum antiviral agents; BSAAs; ZIKA VIRUS-INFECTION; ANIMAL-MODELS; INHIBITS ZIKA; ROTAVIRUS INFECTION; DRUG; REPLICATION; INFLUENZA; SALIPHENYLHALAMIDE; TRANSCRIPTION; OBATOCLAX;

D O I：

10.1016/j.ijid.2020.02.018

中图分类号：

R51 [传染病];

学科分类号：

100201 [内科学];

摘要：

Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

引用

页码：268 / 276

页数：9

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