Physical Fitness and Telomere Length in Patients with Coronary Heart Disease: Findings from the Heart and Soul Study

被引:48
作者
Krauss, Jeffrey [1 ]
Farzaneh-Far, Ramin [2 ]
Puterman, Eli [3 ]
Na, Beeya [4 ]
Lin, Jue [5 ]
Epel, Elissa [3 ]
Blackburn, Elizabeth [5 ]
Whooley, Mary A. [4 ,6 ,7 ]
机构
[1] Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA
[2] Univ Texas SW Med Ctr Dallas, Div Cardiol, Dallas, TX 75390 USA
[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
[4] Vet Affairs Med Ctr, Gen Internal Med Sect, San Francisco, CA 94121 USA
[5] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
[6] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[7] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
关键词
OXIDATIVE STRESS; INSULIN-RESISTANCE; ARTERY-DISEASE; REPLICATIVE SENESCENCE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; ENDOTHELIAL-CELLS; QUANTITATIVE PCR; DNA-DAMAGE; EXERCISE;
D O I
10.1371/journal.pone.0026983
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Background: Short telomere length (TL) is an independent predictor of mortality in patients with coronary heart disease (CHD). However, the relationship between physical fitness and TL has not been explored in these patients. Methods: In a cross sectional study of 944 outpatients with stable CHD, we performed exercise treadmill testing, assessed self-reported physical activity, and measured leukocyte TL using a quantitative PCR assay. We used generalized linear models to calculate mean TL (T/S ratio), and logistic regression models to compare the proportion of patients with short TL (defined as the lowest quartile), among participants with low, medium and high physical fitness, based on metabolic equivalent tasks achieved (METs). Results: 229 participants had low physical fitness (<5 METS), 334 had moderate physical fitness (5-7 METS), and 381 had high physical fitness (>7 METS). Mean +/- T/S ratio ranged from 0.86=0.21 (5349 +/- 3781 base pairs) in those with low physical fitness to 0.95 +/- 0.23 (5566 +/- 3829 base pairs) in those with high physical fitness (p<001). This association remained strong after adjustment for numerous patient characteristics, including measures of cardiac disease severity and physical inactivity (p = 0.005). Compared with participants with high physical fitness, those with low physical fitness had 2-fold greater odds of having TL in the lowest quartile (OR 2.39, 95% CI 1.60-3.55; p<.001). This association was similar after multivariable adjustment (OR 1.94, 95%CI, 1.18-3.20; p = 0.009). Self-reported physical inactivity was associated with shorter TL in unadjusted analyses, but not after multivariable adjustment. Conclusions: We found that worse objectively-assessed physical fitness is associated with shorter leukocyte telomere length in patients with CHD. The clinical implications of this association deserve further study.
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页数:8
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