RAS pathway mutations in Juvenile myelomonocytic leukemia

被引：7

作者：

Emanuel, Peter D. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Winthrop P Rockefeller Canc Inst, Little Rock, AR 72202 USA

来源：

ACTA HAEMATOLOGICA | 2008年 / 119卷 / 04期

关键词：

Juvenile myelomonocytic leukemia; RAS pathway; mutation;

D O I：

10.1159/000140632

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Juvenile myelomonocytic leukemia (JMML) is a rare blood cell malignancy occurring in very young children. Yet, just as has been proven in other rare diseases, the study of JMML has provided us great insights into aberrant and dysregulated signal transduction through the Ras pathway, with the ultimate development of malignancy. Further, JMML investigations have also revealed to us much about the genetic predisposition to cancer. Copyright (c) 2008 S. Karger AG, Basel.

引用

页码：207 / 211

页数：5

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