Inhibition of erbB-2-positive breast cancer cell growth by erbB-2 antisense oligonucleotides

被引:23
作者
Liu, XJ
Pogo, BGT
机构
[1] CUNY MT SINAI SCH MED, DEPT MED, DIV NEOPLAST DIS, NEW YORK, NY 10029 USA
[2] CUNY MT SINAI SCH MED, DEPT MICROBIOL, NEW YORK, NY 10029 USA
来源
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT | 1996年 / 6卷 / 01期
关键词
D O I
10.1089/oli.1.1996.6.9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Overexpression of erbB-2 proto-oncogene has been found in 20%-30% of human breast carcinomas and in most cases correlates with poor clinical prognosis. Using antisense oligonucleotides targeted to the 5' cap region of erbB-2RNA, we were able to inhibit erbB-2 protein expression, proliferation, and anchorage-independent growth of breast cancer cells up to 90%. These effects were sequence specific and restricted to cells expressing elevated level of erbB-2 protein, These results support the feasibility of using antisense erbB-2 oligonucleotides to inhibit the progression of erbB-2-overexpressing breast cancer cells.
引用
收藏
页码:9 / 16
页数:8
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