Malaria parasite transporters as a drug-delivery strategy

被引：33

作者：

Biagini, GA ^{[1
]}

Ward, SA ^{[1
]}

Bray, PG ^{[1
]}

机构：

[1] Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England

来源：

TRENDS IN PARASITOLOGY | 2005年 / 21卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.pt.2005.05.013

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The recent characterization of the choline carrier of the malaria parasite and its role in the selective delivery of novel antimalarial drugs has reignited interest in parasite transporters as a drug-delivery strategy. In this article, we discuss these findings in relation to the wider context of developing a sustainable antimalarial-drug-development portfolio.

引用

页码：299 / 301

页数：3

共 37 条

[31] Furosemide analogues as potent inhibitors of the new permeability pathways of Plasmodium falciparum-infected human erythrocytes [J].

Staines, HM ;

Staines, M ;

Dee, BC ;

O'Brien, M ;

Lang, HJ ;

Englert, H ;

Horner, HA ;

Ellory, JC ;

Kirk, K .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2004, 133 (02) :315-318

[32] Diamidine compounds:: Selective uptake and targeting in Plasmodium falciparum [J].

Stead, AMW ;

Bray, PG ;

Edwards, IG ;

DeKoning, HP ;

Elford, BC ;

Stocks, PA ;

Ward, SA .

MOLECULAR PHARMACOLOGY, 2001, 59 (05) :1298-1306

[33] PARASITE-INDUCED PERMEATION OF NUCLEOSIDES IN PLASMODIUM-FALCIPARUM MALARIA [J].

UPSTON, JM ;

GERO, AM .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1995, 1236 (02) :249-258

[34]

Vial H J, 1999, Novartis Found Symp, V226, P74

[35]

VIAL HJ, 1998, MALARIA PARASITE BIO, P159

[36] A class of potent antimalarials and their specific accumulation in infected erythrocytes [J].

Wengelnik, K ;

Vidal, V ;

Ancelin, ML ;

Cathiard, AM ;

Morgat, JL ;

Kocken, CH ;

Calas, M ;

Herrera, S ;

Thomas, AW ;

Vial, HJ .

SCIENCE, 2002, 295 (5558) :1311-1314

[37] Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs [J].

Zufferey, R ;

Ben Mamoun, C .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2002, 125 (1-2) :127-134

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