Colorectal cancer - Mutations in a signalling pathway

被引:559
作者
Parsons, DW [1 ]
Wang, TL
Samuels, Y
Bardelli, A
Cummins, JM
DeLong, L
Silliman, N
Ptak, J
Szabo, S
Willson, JKV
Markowitz, S
Kinzler, K
Vogelstein, B
Lengauer, C
Velculescu, VE
机构
[1] Johns Hopkins Univ, Inst Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA
[2] Johns Hopkins Univ, Inst Med, Howard Hughes Med Inst, Baltimore, MD 21231 USA
[3] Univ Texas, SW Med Ctr, Harold C Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA
[4] Case Western Reserve Univ, Cleveland, OH 44106 USA
[5] Univ Hosp Cleveland, Howard Hughes Med Inst, Cleveland, OH 44106 USA
[6] Univ Hosp Cleveland, Ireland Canc Ctr, Cleveland, OH 44106 USA
关键词
D O I
10.1038/436792a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 [理学]; 0710 [生物学]; 09 [农学];
摘要
[No abstract available]
引用
收藏
页码:792 / 792
页数:1
相关论文
共 10 条
[1]
Mutational analysis of the tyrosine kinome in colorectal cancers [J].
Bardelli, A ;
Parsons, DW ;
Silliman, N ;
Ptak, J ;
Szabo, S ;
Saha, S ;
Markowitz, S ;
Willson, JKV ;
Parmigiani, G ;
Kinzler, KW ;
Vogelstein, B ;
Velculescu, VE .
SCIENCE, 2003, 300 (5621) :949-949
[2]
Oncogenic kinase signalling [J].
Blume-Jensen, P ;
Hunter, T .
NATURE, 2001, 411 (6835) :355-365
[3]
Mutations of the BRAF gene in human cancer [J].
Davies, H ;
Bignell, GR ;
Cox, C ;
Stephens, P ;
Edkins, S ;
Clegg, S ;
Teague, J ;
Woffendin, H ;
Garnett, MJ ;
Bottomley, W ;
Davis, N ;
Dicks, N ;
Ewing, R ;
Floyd, Y ;
Gray, K ;
Hall, S ;
Hawes, R ;
Hughes, J ;
Kosmidou, V ;
Menzies, A ;
Mould, C ;
Parker, A ;
Stevens, C ;
Watt, S ;
Hooper, S ;
Wilson, R ;
Jayatilake, H ;
Gusterson, BA ;
Cooper, C ;
Shipley, J ;
Hargrave, D ;
Pritchard-Jones, K ;
Maitland, N ;
Chenevix-Trench, G ;
Riggins, GJ ;
Bigner, DD ;
Palmieri, G ;
Cossu, A ;
Flanagan, A ;
Nicholson, A ;
Ho, JWC ;
Leung, SY ;
Yuen, ST ;
Weber, BL ;
Siegler, HF ;
Darrow, TL ;
Paterson, H ;
Marais, R ;
Marshall, CJ ;
Wooster, R .
NATURE, 2002, 417 (6892) :949-954
[4]
A census of human cancer genes [J].
Futreal, PA ;
Coin, L ;
Marshall, M ;
Down, T ;
Hubbard, T ;
Wooster, R ;
Rahman, N ;
Stratton, MR .
NATURE REVIEWS CANCER, 2004, 4 (03) :177-183
[5]
The protein kinase complement of the human genome [J].
Manning, G ;
Whyte, DB ;
Martinez, R ;
Hunter, T ;
Sudarsanam, S .
SCIENCE, 2002, 298 (5600) :1912-+
[6]
High frequency of mutations of the PIK3CA gene in human cancers [J].
Samuels, Y ;
Wang, ZH ;
Bardelli, A ;
Silliman, N ;
Ptak, J ;
Szabo, S ;
Yan, H ;
Gazdar, A ;
Powell, DM ;
Riggins, GJ ;
Willson, JKV ;
Markowitz, S ;
Kinzler, KW ;
Vogelstein, B ;
Velculescu, VE .
SCIENCE, 2004, 304 (5670) :554-554
[7]
Teng DHF, 1997, CANCER RES, V57, P4177
[8]
The phosphatidylinositol 3-kinase-AKT pathway in human cancer [J].
Vivanco, I ;
Sawyers, CL .
NATURE REVIEWS CANCER, 2002, 2 (07) :489-501
[9]
Digital karyotyping [J].
Wang, TL ;
Maierhofer, C ;
Speicher, MR ;
Lengauer, C ;
Vogelstein, B ;
Kinzler, KW ;
Velculescu, VE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (25) :16156-16161
[10]
PAK4 is activated via PI3K in HGF-stimulated epithelial cells [J].
Wells, CM ;
Abo, A ;
Ridley, AJ .
JOURNAL OF CELL SCIENCE, 2002, 115 (20) :3947-3956