Microbial pathogenesis: Lipid rafts as pathogen portals

被引:133
作者
Rosenberger, CM [1 ]
Brumell, JH
Finlay, BB
机构
[1] Univ British Columbia, Biotechnol Lab, Vancouver, BC V6T 1Z3, Canada
[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada
[3] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
D O I
10.1016/S0960-9822(00)00788-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The route of initial entry influences how host cells respond to intracellular pathogens. Recent studies have demonstrated that a wide variety of pathogens target lipid microdomains in host cell membranes, known as lipid rafts, to enter host cells as an infectious strategy.
引用
收藏
页码:R823 / R825
页数:3
相关论文
共 23 条
  • [1] Adventures of a pore-forming toxin at the target cell surface
    Abrami, L
    Fivaz, M
    van der Goot, FG
    [J]. TRENDS IN MICROBIOLOGY, 2000, 8 (04) : 168 - 172
  • [2] CAVEOLAE - WHERE INCOMING AND OUTGOING MESSENGERS MEET
    ANDERSON, RGW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) : 10909 - 10913
  • [3] The caveolae membrane system
    Anderson, RGW
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 : 199 - 225
  • [4] Survival of FimH-expressing enterobacteria in macrophages relies on glycolipid traffic
    Baorto, DM
    Gao, ZM
    Malaviya, R
    Dustin, ML
    vanderMerwe, A
    Lublin, DM
    Abraham, SN
    [J]. NATURE, 1997, 389 (6651) : 636 - 639
  • [5] A coat protein on phagosomes involved in the intracellular survival of mycobacteria
    Ferrari, G
    Langen, H
    Naito, M
    Pieters, J
    [J]. CELL, 1999, 97 (04) : 435 - 447
  • [6] Essential role for cholesterol in entry of mycobacteria into macrophages
    Gatfield, J
    Pieters, J
    [J]. SCIENCE, 2000, 288 (5471) : 1647 - 1650
  • [7] COOH-terminal sequence of the cellular prion protein directs subcellular trafficking and controls conversion into the scrapie isoform
    Kaneko, K
    Vey, M
    Scott, M
    Pilkuhn, S
    Cohen, FE
    Prusiner, SB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) : 2333 - 2338
  • [8] Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
    Malaviya, R
    Ikeda, T
    Ross, E
    Abraham, SN
    [J]. NATURE, 1996, 381 (6577) : 77 - 80
  • [9] The mast cell tumor necrosis factor α response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48
    Malaviya, R
    Gao, ZM
    Thankavel, K
    van der Merwe, PA
    Abraham, SN
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) : 8110 - 8115
  • [10] Membrane raft microdomains mediate front-rear polarity in migrating cells
    Mañes, S
    Mira, E
    Gómez-Moutón, C
    Lacalle, RA
    Keller, P
    Labrador, JP
    Martínez-A, C
    [J]. EMBO JOURNAL, 1999, 18 (22) : 6211 - 6220