The thioredoxin system - From science to clinic

被引：377

作者：

Gromer, S

Urig, S

Becker, K

机构：

[1] Zentrum Biochem, D-69120 Heidelberg, Germany

[2] Interdisziplinares Forsch Zentrum, D-35392 Giessen, Germany

来源：

MEDICINAL RESEARCH REVIEWS | 2004年 / 24卷 / 01期

关键词：

thioredoxin; thioredoxin reductase; selenium; cancer; inhibitor;

D O I：

10.1002/med.10051

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The thioredoxin system-formed by thioredoxin reductase and its characteristic substrate thioredoxin-is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA-synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine-ranging from infectious diseases to cancer therapy. In this review we will present and evaluate the preclinical and clinical results available today. Current trends in drug development are emphasized. (C) 2003 Wiley Periodicals, Inc.

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页码：40 / 89

页数：50

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