Immune-mediated complications of the graft in interferon-treated hepatitis C positive liver transplant recipients

被引：74

作者：

Selzner, Nazia ^{[1
]}

Guindi, Maha ^{[2
]}

Renner, Eberhard L. ^{[1
]}

Berenguer, Marina ^{[3
,4
]}

机构：

[1] Univ Toronto, Univ Hlth Network, Multi Organ Transplant Program 1, Toronto, ON, Canada

[2] Univ Toronto, Dept Pathol, Univ Hlth Network, Toronto, ON, Canada

[3] Hosp La Fe, Hepatol Unit, E-46009 Valencia, Spain

[4] Hosp La Fe, Ctr Invest Biomed Red Enfermedades Hepat & Digest, E-46009 Valencia, Spain

来源：

JOURNAL OF HEPATOLOGY | 2011年 / 55卷 / 01期

关键词：

Acute cellular rejection; Chronic rejection; Autoimmune hepatitis; Chronic hepatitis C infection; NOVO AUTOIMMUNE HEPATITIS; PLASMA-CELL HEPATITIS; SUSTAINED VIROLOGICAL RESPONSE; PEGYLATED-INTERFERON; ANTIVIRAL THERAPY; NATURAL-HISTORY; CENTRAL PERIVENULITIS; VIRUS-INFECTION; PEG-INTERFERON; PLUS RIBAVIRIN;

D O I：

10.1016/j.jhep.2010.11.012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis C virus (HCV) re-infection of the graft is universal and interferon based antiviral therapy remains at present the treatment of choice in HCV liver transplant recipients. Apart from the antiviral effects, interferon and ribavirin have both potent immunomodulatory properties resulting in a broad range of immune-related disorders including acute cellular rejection and chronic ductopenic rejection as well as de HCV autoimmune hepatitis. Further complicating the picture, HCV infection per se is associated with a variety of autoimmune phenomena. We discuss here the immune-mediated complications and their relationship to chronic HCV and interferon based antiviral therapy. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：207 / 217

页数：11

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